Evidence map›Paper›PMID 27454317›Full record

ArticleGene therapy2016

Electroporation-mediated delivery of the FER gene in the resolution of trauma-related fatal pneumonia.

V A Dolgachev, R Goldberg, M V Suresh, B Thomas, N Talarico, M R Hemmila, K Raghavendran, D Machado-Aranda

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Pulmonary gene delivery-Realities and possibilities.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  6. Review
  7. Review
  8. Direct pulmonary delivery of solubilized curcumin reduces severity of lethal pneumonia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

V A DolgachevDivision of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
R GoldbergDivision of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
M V SureshDivision of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
B ThomasDivision of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
N TalaricoDivision of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
M R HemmilaDivision of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
K RaghavendranDivision of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
D Machado-ArandaDivision of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-3716-962X
University of Michigan · US

Funding

Mechanisms of MCP-1 in lung contusion with and without gastric aspirationR01HL102013 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAGHAVENDRAN, KRISHNAN · 2010 to 2013
$1.5M
Regulation of Hypoxia Inducible Factor -1α in Alveolar Epithelial Cells in Lung ContusionR01GM111305 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAGHAVENDRAN, KRISHNAN · 2015 to 2018
$1.3M
NHLBI NIH HHS R01 HL102013
6 · The paper itself

Abstract

Injured patients with lung contusion (LC) are at risk of developing bacterial pneumonia (PNA) followed by sepsis and death. A recent genome-wide association study (GWAS) showed FER gene expression positively correlating with survival rates among individuals with above conditions. We sought to determine whether electroporation (EP)-mediated delivery of FER gene could indeed improve survival, in a lethal model of combined LC and PNA. C57BL/6 mice sustained unilateral LC, which preceded a 500 Klebsiella colony forming unit (CFU) inoculation by 6 h. In-between these insults, human FER plasmid (pFER) was introduced into the lungs followed by eight EP pulses applied externally (10 ms at 200 V cm

Indexed as

ElectroporationGenetic TherapyAnimalsBacterial LoadContusionsGenetic VectorsHumansKlebsiellaMaleMiceMice, Inbred C57BLPneumonia, BacterialProtein-Tyrosine KinasesSodium-Potassium-Exchanging ATPaseProtein-Tyrosine Kinasesproto-oncogene protein c-fes-fpsSodium-Potassium-Exchanging ATPase

Identifiers

PMID27454317
PMCPMC5096957
OpenAlexW2480891847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.