ArticleScience advances2016
Heterogeneity of cellular circadian clocks in intact plants and its correction under light-dark cycles.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- An order parameter for synchronisation of angular velocities.The European physical journal. Special topics · 2026Article
- A CRISPR/Cas9-induced restoration of bioluminescence reporter system for single-cell gene expression analysis in plants.Scientific reports · 2025Article
- Machine learning assisted analysis of rice flower opening times using a low-cost time-lapse camera.Journal of plant research · 2025Article
- Model-based analysis of the circadian rhythm generation of bioluminescence reporter activity in duckweed.Plant biotechnology (Tokyo, Japan) · 2025Article
- 48-Hour and 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms in Arabidopsis.Nature communications · 2025Article
- Extracellular vesicle GABA responds to cadmium stress, and GAD overexpression alleviates cadmium damage in duckweed.Frontiers in plant science · 2025Article
- Dissecting the complexity of local and systemic circadian communication in plants.Npj biological timing and sleep · 2024Review
- Low-temperature and circadian signals are integrated by the sigma factor SIG5.Nature plants · 2023Article
- Circadian clock does not play an essential role in daylength measurement for growth-phase transition inFrontiers in plant science · 2023Article
- Spatially specific mechanisms and functions of the plant circadian clock.Plant physiology · 2022Review
- Circadian and diel regulation of photosynthesis in the bryophyte Marchantia polymorpha.Plant, cell & environment · 2022Article
- Circadian-period variation underlies the local adaptation of photoperiodism in the short-day plantiScience · 2022Article
- A spatial model of the plant circadian clock reveals design principles for coordinated timing.Molecular systems biology · 2022Article
- Critical Evaluation of Specific Efficacy of Preparations Produced According to European Pharmacopeia Monograph 2371.Biomedicines · 2022Article
- Comparative Phenotyping of Two Commonly UsedPlants (Basel, Switzerland) · 2022Article
- The biology of time: dynamic responses of cell types to developmental, circadian and environmental cues.The Plant journal : for cell and molecular biology · 2022Review
- Review
- Synchronization of gene expression across eukaryotic communities through chemical rhythms.Nature communications · 2021Article
- Review
- Characterization of Frond and Flower Development and Identification of FT and FD Genes From DuckweedFrontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in single-cell analysis have revealed the stochasticity and nongenetic heterogeneity inherent to cellular processes. However, our knowledge of the actual cellular behaviors in a living multicellular organism is still limited. By using a single-cell bioluminescence imaging technique on duckweed, Lemna gibba, we demonstrate that, under constant conditions, cells in the intact plant work as individual circadian clocks that oscillate with their own frequencies and respond independently to external stimuli. Quantitative analysis uncovered the heterogeneity and instability of cellular clocks and partial synchronization between neighboring cells. Furthermore, we found that cellular clocks in the plant body under light-dark cycles showed a centrifugal phase pattern in which the effect of cell-to-cell heterogeneity in period lengths was almost masked. The inherent heterogeneity in the properties of cellular clocks observed under constant conditions is corrected under light-dark cycles to coordinate the daily rhythms of the plant body. These findings provide a novel perspective of spatiotemporal architectures in the plant circadian system.
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