Evidence map›Paper›PMID 27453936›Full record

ArticleAmerican journal of robotic surgery2015

Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Genetic Engineering: Robotic Genetic Surgery.

Kaivalya Deshpande, Arpita Vyas, Archana Balakrishnan, Dinesh Vyas

Open access · greenAbstract read
In one paragraph

Article in American journal of robotic surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Genome Editing and Heart Failure.Advances in experimental medicine and biology · 2023
    Article
  4. Review
  5. Review
  6. Review
  7. The protean world of non-coding RNAs in glioblastoma.Journal of molecular medicine (Berlin, Germany) · 2019
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kaivalya DeshpandeCollege of Human Medicine, Michigan State University, East Lansing, MI 48824, United States.
Arpita VyasCollege of Human Medicine, Michigan State University, East Lansing, MI 48824, United States.
Archana BalakrishnanCollege of Human Medicine, Michigan State University, East Lansing, MI 48824, United States.
Dinesh VyasTexas Tech University Health Sciences Center, Department of Surgery, 61391 ODE Surgery.
Michigan State University · US

Funding

Building Interdisciplinary Research Careers in Women's Health at Michigan StateK12HD065879 · NICHD · MICHIGAN STATE UNIVERSITY · PI HOLZMAN, CLAUDIA B. · 2010 to 2014
$2.5M
NICHD NIH HHS K12 HD065879
6 · The paper itself

Abstract

As a novel technology that utilizes the endogenous immune defense system in bacteria, CRISPR/Cas9 has transcended DNA engineering into a more pragmatic and clinically efficacious field. Using programmable sgRNA sequences and nucleases, the system effectively introduces double strand breaks in target genes within an entire organism. The applications of CRISPR range from biomedicine to drug development and epigenetic modification. Studies have demonstrated CRISPR mediated targeting of various tumorigenic genes and effector proteins known to be involved in colon carcinomas. This technology significantly expands the scope of gene manipulation and allows for an enhanced modeling of colon cancers, as well as various other malignancies.

Indexed as

BiotechnologyCRISPR/Cas9DNA EngineeringGeneticsRobotics

Identifiers

PMID27453936
PMCPMC4957700
OpenAlexW2339905080

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.