Evidence map›Paper›PMID 27453929›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2016

A blood screening test for Alzheimer's disease.

Sid E O'Bryant, Melissa Edwards, Leigh Johnson, James Hall, Alcibiades E Villarreal, Gabrielle B Britton, Mary Quiceno, C Munro Cullum, Neill R Graff-Radford

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
35.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Blood-based biomarkers for Alzheimer's disease in Down syndrome: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
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  10. Precision medicine for Alzheimer's disease in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  18. Observational
  19. A Blood Screening Test for Dementia with Lewy Bodies for Primary Care.Journal of Alzheimer's disease & Parkinsonism · 2023
    Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Sid E O'BryantInstitute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
Melissa EdwardsDepartment of Psychology, University of North Texas, Denton, TX, USA.
Leigh JohnsonInstitute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
James HallInstitute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
Alcibiades E VillarrealCentro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber, Panamá, Panamá; Department of Biotechnology, Acharya Nagarjuna University, Guntur, India.
Gabrielle B BrittonCentro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber, Panamá, Panamá
Mary QuicenoDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
C Munro CullumDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Neill R Graff-RadfordDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
University of North Texas · USThe University of Texas Southwestern Medical Center · USAcharya Nagarjuna University · INInstituto de Investigaciones Científicas y Servicios de Alta Tecnología · PAJacksonville College · US

Funding

ROLE OF GLUTAMATE IN ALZHEIMER'S DISEASEP30AG012300 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI ROSENBERG, ROGER NEWMAN · 1994 to 2016
$26.6M
A Blood-Based Screening Tool for Alzheimer's DiseaseR01AG039389 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E · 2012 to 2013
$608k
NIA NIH HHS P30 AG012300NIA NIH HHS R01 AG039389
6 · The paper itself

Abstract

introductionThis study combined data across four independent cohorts to examine the positive and negative predictive values of an Alzheimer's disease (AD) blood test if implemented in primary care.

methodsBlood samples from 1329 subjects from multiple independent, multiethnic, community-based, and clinic-based cohorts were analyzed. A "locked-down" referent group of 1128 samples was generated with 201 samples randomly selected for validation purposes. Random forest analyses were used to create the AD blood screen. Positive (PPV) and negative (NPV) predictive values were calculated.

resultsIn detecting AD, PPV was 0.81, and NPV was 0.95 while using the full AD blood test. When detecting mild cognitive impairment, PPV and NPV were 0.74 and 0.93, respectively. Preliminary analyses were conducted to detect any "neurodegenerative disease". The full 21-protein AD blood test yielded a PPV of 0.85 and NPV of 0.94. DISCUSSION: The present study creates the first-ever multiethnic referent sample that spans community-based and clinic-based populations for implementation of an AD blood screen.

Indexed as

Alzheimer's diseaseBlood testDiagnosisPredictive powerPrimary careScreening

Identifiers

PMID27453929
PMCPMC4941038
OpenAlexW2473283057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.