Evidence map›Paper›PMID 27453775›Full record

ArticleClinical and translational allergy2016

Atopic dermatitis prevention in children following maternal probiotic supplementation does not appear to be mediated by breast milk TSLP or TGF-β.

Melanie Rae Simpson, Anne Dorthea Bjerkenes Rø, Øystein Grimstad, Roar Johnsen, Ola Storrø, Torbjørn Øien

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational allergy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00159523 (The Impact of Perinatal Daily Supplement of a Probiotic), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00159523 nacompletednot on this map

The Impact of Perinatal Daily Supplement of a Probiotic (Lactobacillus Rhamnosus GG), Given to Mothers, on Immunological Development, Atopic Sensitisation and Allergic Disease in Their Off-spring

TypeinterventionalSponsorNorwegian University of Science and TechnologyRan2003 to 2007Enrolled416ConditionsAsthma, Dermatitis, Atopic, Rhinitis, Allergic, PerennialArmsProbiotic, placebo
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Can Mixed Strains ofNutrients · 2021
    Pooled it
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Melanie Rae SimpsonDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway ; Det medisinske fakultet, Instiutt for samfunnsmedisin, MTFS, NTNU, Postboks 8905, 7491 Trondheim, Norway.
Anne Dorthea Bjerkenes RøDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway ; Department of Immunology and Transfusion Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Øystein GrimstadDepartment of Dermatology, University Hospital of North Norway, Tromsö, Norway.
Roar JohnsenDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
Ola StorrøDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
Torbjørn ØienDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
Norwegian University of Science and Technology · NOUniversity Hospital of North Norway · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Probiotics in Prevention of Allergy among Children in Trondheim (ProPACT) study, a randomised, placebo controlled trial, demonstrated that maternal supplementation with probiotic milk reduced the incidence of atopic dermatitis (AD) in infancy. The mechanisms behind this effect are incompletely understood and breast milk cytokines have been postulated as possible mediating factors. In this study we aimed to assess whether breast milk TLSP and TGF-β are affected by a maternal probiotic supplementation regime, and their contribution to the preventive effect of this regime on AD in the offspring.

methodsTSLP and TGF-β isoforms (TGF-β1, TGF-β2 and TGF-β3) were measured using ELISA and multiplex assays, respectively, in breast milk samples collected at 10 days and 3 months postpartum from women participating in the ProPACT trial (n = 259). The natural indirect and direct effects of maternal probiotics on AD, due to changes in breast milk cytokines, were estimated using causal mediation techniques.

resultsProbiotic supplementation tend to lead to high levels of breast milk TSLP at 10 days postpartum (p = 0.062), but this change did not contribute to the prevention of AD according to the mediation analysis. Probiotics had no apparent effect on TSLP at 3 months or TGF-βs at either time points. Thus, these are unlikely to be mediators of the effect of maternal probiotics on AD in offspring.

conclusionsWhilst maternal probiotic supplementation resulted in higher breast milk concentrations of TLSP at 10 days postpartum, this does not appear to be a mechanism for prevention of AD by maternal probiotics. Trial registration The original trial protocol is registered in ClinicalTrials.gov (identifier NCT00159523).

Identifiers

PMID27453775
PMCPMC4957279
OpenAlexW2468356418

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.