Evidence map›Paper›PMID 27453773›Full record

ArticleMedChemComm2016

Effect of intercalator and Lewis acid-base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNA.

Jessica E Wynn, Wenyu Zhang, Denis M Tebit, Laurie R Gray, Marie-Louise Hammarskjold, David Rekosh, Webster L Santos

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jessica E WynnDepartment of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24060, USA.
Wenyu ZhangDepartment of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24060, USA.
Denis M TebitDepartment of Microbiology, Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, VA 22904, USA.
Laurie R GrayDepartment of Microbiology, Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, VA 22904, USA.
Marie-Louise HammarskjoldDepartment of Microbiology, Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, VA 22904, USA.
David RekoshDepartment of Microbiology, Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, VA 22904, USA.
Webster L SantosDepartment of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24060, USA.
Charlottesville Medical Research · USVirginia Tech · USUniversity of Virginia · US

Funding

RNA As A Therapeutic TargetR01GM093834 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SANTOS, WEBSTER L · 2010 to 2014
$1.6M
Functional Variation of Rev and RRE Activity During HIV InfectionR01GM110009 · NIGMS · UNIVERSITY OF VIRGINIA · PI HAMMARSKJOLD, MARIE-LOUISE, REKOSH, DAVID M · 2013 to 2016
$1.2M
NIGMS NIH HHS R01 GM093834NIGMS NIH HHS R01 GM110009
6 · The paper itself

Abstract

High throughput screening of a 4096 compound library of boronic acid and acridine containing branched peptides revealed compounds that have dissociation constants in the low nanomolar regime for HIV-1 RRE IIB RNA. We demonstrate that branched peptide boronic acids

Identifiers

PMID27453773
PMCPMC4957400
OpenAlexW2418336724

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.