Evidence map›Paper›PMID 27453598›Full record

ArticlePublic health reports (Washington, D.C. : 1974)

Performance of Risk-Based and Birth-Cohort Strategies for Identifying Hepatitis C Virus Infection Among People Entering Prison, Wisconsin, 2014.

Lauren J Stockman, James Greer, Ryan Holzmacher, Beth Dittmann, Scott A Hoftiezer, Lori E Alsum, Audrey Prieve, Ryan P Westergaard, Sheila M Guilfoyle, James M Vergeront

Abstract read
In one paragraph

Article in Public health reports (Washington, D.C. : 1974). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lauren J StockmanWisconsin Department of Health Services, Division of Public Health, AIDS/HIV Program, Madison, WI.
James GreerWisconsin Department of Corrections, Bureau of Health Services, Madison, WI.
Ryan HolzmacherWisconsin Department of Corrections, Bureau of Health Services, Madison, WI.
Beth DittmannWisconsin Department of Corrections, Bureau of Health Services, Madison, WI.
Scott A HoftiezerWisconsin Department of Corrections, Bureau of Health Services, Madison, WI.
Lori E AlsumWisconsin Department of Corrections, Bureau of Health Services, Madison, WI.
Audrey PrieveWisconsin State Laboratory of Hygiene, Communicable Disease Division, Madison, WI.
Ryan P WestergaardUniversity of Wisconsin School of Medicine and Public Health, Department of Medicine, Division of Infectious Disease, Madison, WI.
Sheila M GuilfoyleWisconsin Department of Health Services, Division of Public Health, AIDS/HIV Program, Madison, WI.
James M VergerontWisconsin Department of Health Services, Division of Public Health, AIDS/HIV Program, Madison, WI.

Funding

Barriers to Effective HIV Care for Injection Drug Users After Release from PrisonK23DA032306 · NIDA · UNIVERSITY OF WISCONSIN-MADISON · PI WESTERGAARD, RYAN PATRICK · 2012 to 2016
$975k
NIDA NIH HHS K23 DA032306
6 · The paper itself

Abstract

objectivesThe prevalence of hepatitis C virus (HCV) infection among young adults is rising in Wisconsin. We examined the prevalence of HCV infection among male and female inmates entering two Wisconsin prisons and evaluated existing and alternate risk-based strategies for identifying HCV infection at intake.

methodsWe added HCV testing to the intake procedures for all 1,239 adults prison entrants at the Wisconsin Department of Corrections (WDOC) from November 3, 2014, to January 31, 2015. We identified risk factors associated with HCV infection during the routine intake examination and calculated the sensitivity and specificity of risk-based testing strategies for identifying HCV infection.

resultsThe prevalence of HCV antibody among prison entrants was 12.5% (95% confidence interval [CI] 10.7, 14.4) overall and was almost two times higher at the women's facility (21.3%, 95% CI 15.4, 27.2) than at the men's facility (11.0%, 95% CI 0.0, 12.9) (p<0.001). The sensitivity and specificity of the WDOC risk-based criteria were 88% (95% CI 83, 93) and 80% (95% CI 78, 83), respectively. Adding a new criterion, the 1945-1965 birth cohort, to the risk-based criteria improved the sensitivity to 92% (95% CI 88, 96) and lowered the specificity to 71% (95% CI 68, 74). Compared with entrants without these risk factors, HCV antibody prevalence was significantly higher among prison entrants who had the following risk factors: injection drug use (prevalence ratio [PR] = 9.9, 95% CI 7.4, 13.2), liver disease (PR=9.7, 95% CI 7.8, 12.0), and elevated levels of alanine transaminase (PR=3.6, 95% CI 2.7, 4.9).

conclusionThe WDOC risk criteria for HCV testing identified 88% of HCV infections among prison entrants. Including the 1945-1965 birth cohort as a criterion along with the other WDOC risk criteria increased the sensitivity of targeted testing to 92%. These findings may be informative to jurisdictions where universal HCV testing is not feasible because of resource limitations.

Indexed as

PrisonersAdultAgedFemaleHepacivirusHepatitis CHepatitis C AntibodiesHumansMaleMiddle AgedPrevalenceRisk FactorsWisconsinHepatitis C Antibodies

Identifiers

PMID27453598
PMCPMC4937115

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.