ArticleCell systems2016
Switch-like Transitions Insulate Network Motifs to Modularize Biological Networks.
Article in Cell systems, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Article
- Context-dependent regulation of lipid accumulation in adipocytes by a HIF1α-PPARγ feedback network.Cell systems · 2023Article
- Oscillator death in coupled biochemical oscillators.Mathematics of control, signals, and systems : MCSS · 2023Article
- Network topology-directed design of molecular CPU for cell-like dynamic information processing.Science advances · 2022Article
- A microRNA or messenger RNA point of departure estimates an apical endpoint point of departure in a rat developmental toxicity model.Birth defects research · 2022Article
- A numerical approach for detecting switch-like bistability in mass action chemical reaction networks with conservation laws.BMC bioinformatics · 2022Article
- A modular approach for modeling the cell cycle based on functional response curves.PLoS computational biology · 2021Article
- Constitutive expression of a fluorescent protein reports the size of live human cells.Molecular biology of the cell · 2019Article
- Modeling population dynamics in a microbial consortium under control of a synthetic pheromone-mediated communication system.Engineering in life sciences · 2019Article
- Eternal sunshine of the spotless cycle.Molecular systems biology · 2019Article
- Function, dynamics and evolution of network motif modules in integrated gene regulatory networks of worm and plant.Nucleic acids research · 2018Article
- Inferring a nonlinear biochemical network model from a heterogeneous single-cell time course data.Scientific reports · 2018Article
- Spatial and temporal signal processing and decision making by MAPK pathways.The Journal of cell biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Cellular decisions are made by complex networks that are difficult to analyze. Although it is common to analyze smaller sub-networks known as network motifs, it is unclear whether this is valid, because these motifs are embedded in complex larger networks. Here, we address the general question of modularity by examining the S. cerevisiae pheromone response. We demonstrate that the feedforward motif controlling the cell-cycle inhibitor Far1 is insulated from cell-cycle dynamics by the positive feedback switch that drives reentry to the cell cycle. Before cells switch on positive feedback, the feedforward motif model predicts the behavior of the larger network. Conversely, after the switch, the feedforward motif is dismantled and has no discernable effect on the cell cycle. When insulation is broken, the feedforward motif no longer predicts network behavior. This work illustrates how, despite the interconnectivity of networks, the activity of motifs can be insulated by switches that generate well-defined cellular states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.