ArticleThe Journal of pediatrics2016
Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns.
Article in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Magnesium sulfate for fetal neuroprotection in preterm pregnancy: a meta-analysis of randomized controlled trials.BMC pregnancy and childbirth · 2024Pooled it
- A Systematic Review of Magnesium Sulfate for Perinatal Neuroprotection: What Have We Learnt From the Past Decade?Frontiers in neurology · 2020Pooled it
- Antenatal magnesium sulphate and adverse neonatal outcomes: A systematic review and meta-analysis.PLoS medicine · 2019Pooled it
- Cerebellar Hemorrhage in Preterm Infants: A Meta-Analysis on Risk Factors and Neurodevelopmental Outcome.Frontiers in physiology · 2019Pooled it
- Prenatal Magnesium Sulfate and Functional Connectivity in Offspring at Term-Equivalent Age.JAMA network open · 2024Trial
- Extending the Branches of Neonatal Neurocritical Care.Seminars in perinatology · 2025Review
- Reevaluating the association between chorioamnionitis and cerebellar hemorrhage: A systematic review and meta-analysis.Pregnancy (Hoboken, N.J.) · 2025Review
- Cerebellar hemorrhage in neonates: pattern analysis by ultrasonography and magnetic resonance imaging.Pediatric radiology · 2025Article
- Fibrinogen inhibits sonic hedgehog signaling and impairs neonatal cerebellar development after blood-brain barrier disruption.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Regional cerebral oxygen saturation variability and brain injury in preterm infants.Frontiers in pediatrics · 2024Article
- Effect of Neuroprotective Magnesium Sulfate Treatment on Brain Transcription Response to Hypoxia Ischemia in Neonate Mice.International journal of molecular sciences · 2021Article
- Cerebellar hemorrhage: a 10-year evaluation of risk factors.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2020Article
- Incidence of Adverse Drug Reactions in High-Risk Pregnancy: A Prospective Cohort Study in Obstetric Intensive Care.European journal of clinical pharmacology · 2020Observational
- Incidence and Risk Factors for Hypoglycemia During Fetal-to-Neonatal Transition in Premature Infants.Frontiers in pediatrics · 2020Article
- Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Umbilical cord milking reduces the risk of intraventricular hemorrhage in preterm infants born before 32 weeks of gestation.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Recent advances in perinatal neuroprotection.F1000Research · 2019Review
- Divergent risk factors for cerebellar and intraventricular hemorrhage.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Article
- Fetal Neuroprotection by Magnesium Sulfate: From Translational Research to Clinical Application.Frontiers in neurology · 2018Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine the association of antenatal magnesium sulfate with cerebellar hemorrhage in a prospective cohort of premature newborns evaluated by magnetic resonance imaging (MRI). STUDY
designCross-sectional analysis of baseline characteristics from a prospective cohort of preterm newborns (<33 weeks gestation) evaluated with 3T-MRI shortly after birth. Exclusion criteria were clinical evidence of a congenital syndrome, congenital infection, or clinical status too unstable for transport to MRI. Antenatal magnesium sulfate exposure was abstracted from the medical records and the indication was classified as obstetric or neuroprotection. Two pediatric neuroradiologists, blinded to the clinical history, scored axial T2-weighted and iron susceptibility MRI sequences for cerebellar hemorrhage. The association of antenatal magnesium sulfate with cerebellar hemorrhage was evaluated using multivariable logistic regression, adjusting for postmenstrual age at MRI and known predictors of cerebellar hemorrhage.
resultsCerebellar hemorrhage was present in 27 of 73 newborns (37%) imaged at a mean ± SD postmenstrual age of 32.4 ± 2 weeks. Antenatal magnesium sulfate exposure was associated with a significantly reduced risk of cerebellar hemorrhage. Adjusting for postmenstrual age at MRI, and predictors of cerebellar hemorrhage, antenatal magnesium sulfate was independently associated in our cohort with decreased cerebellar hemorrhage (OR, 0.18; 95% CI, 0.049-0.65; P = .009).
conclusionAntenatal magnesium sulfate exposure is independently associated with a decreased risk of MRI-detected cerebellar hemorrhage in premature newborns, which could explain some of the reported neuroprotective effects of magnesium sulfate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.