ArticleChinese medical journal2016
A Novel Tectonic Keratoplasty with Femtosecond Laser Intrastromal Lenticule for Corneal Ulcer and Perforation.
Article in Chinese medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Efficacy and safety of small-incision corneal intrastromal lenticule implantation for hyperopia correction: a systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Management of corneal perforations in dry eye disease: Preferred practice pattern guidelines.Indian journal of ophthalmology · 2023Guideline
- Preservation and Reuse of KLEx Lenticules: From Biobanking to Therapeutic and Refractive Innovations.Bioengineering (Basel, Switzerland) · 2026Review
- Biological assessment and preservation strategies for SMILE- derived lenticules: towards a corneal regenerative biobank.Scientific reports · 2026Article
- Femtosecond Laser-Assisted Keratoplasty: A Narrative Review of Technological Evolution, Clinical Evidence, Implementation and Future Directions.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Morphological changes after corneal stromal lenticule excimer laser shaping.Experimental and therapeutic medicine · 2025Article
- Treatment of Corneal Epithelium Lesions with Plasma Rich in Growth Factors: A Case Series and Implications.Healthcare (Basel, Switzerland) · 2025Article
- Ultrastructural changes of corneal stromal lenticule after laser shaping.Experimental and therapeutic medicine · 2025Article
- The Preservation and Reuse of Lenticules Extracted via Small Incision Lenticule Extraction (SMILE): A Narrative Review.Bioengineering (Basel, Switzerland) · 2025Review
- A novel sandwich technique of minimally invasive surgery for corneal perforation.Scientific reports · 2024Observational
- Banking of post-SMILE stromal lenticules for additive keratoplasty: A new challenge for eye banks?International ophthalmology · 2024Review
- Allogenic Lenticular Implantation for Correction of Refractive Error and Ectasia: Narrative Review.Ophthalmology and therapy · 2023Review
- Impact of Latent Virus Infection in the Cornea on Corneal Healing after Small Incision Lenticule Extraction.Microorganisms · 2023Article
- SMILE lenticule versus amniotic membrane graft (AMG) augmented with platelet-rich plasma (PRP) for the treatment of perforated corneal ulcer.International ophthalmology · 2023Article
- Derivation of Human Corneal Keratocytes from ReLEx SMILE Lenticules for Cell Therapy and Tissue Engineering.International journal of molecular sciences · 2023Article
- Update of Research Progress on Small Incision Lenticule Extraction (SMILE) Lenticule Reuse.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Treatment of corneal dermoid with lenticules from small incision lenticule extraction surgery: a surgery assisted by fibrin glue.International journal of ophthalmology · 2023Article
- Therapeutic and tectonic keratoplasty with simple cryopreserved remnants of donor corneas: an 11 year retrospective case series.Scientific reports · 2022Article
- Long-Term Clinical Outcomes of Small-Incision Femtosecond Laser-Assisted Intracorneal Concave Lenticule Implantation in Patients with Keratoconus.Journal of ophthalmology · 2022Article
- Surgical Management of Peripheral Ulcerative Keratitis: Update on Surgical Techniques and Their Outcome.Clinical ophthalmology (Auckland, N.Z.) · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmall incision refractive lenticule extraction (SMILE) is an effective laser procedure that treats myopia. This research was to describe a novel approach to treat corneal ulcer or perforation using the corneal lenticules obtained from SMILE and to evaluate the safety and effectiveness of tectonic keratoplasty with femtosecond laser intrastromal lenticule (TEKIL).
methodsA total of twenty patients (22 eyes) were monitored for at least 6 months and were assessed using slit lamp microscopy, optical coherence tomography, and best-corrected visual acuity (BCVA). Postoperative complications throughout the study period were recorded.
resultsCorneal ulcer in 14 patients (16 eyes) and corneal perforation in six patients (6 eyes) were treated with TEKIL. The patients were ten females and ten males, with a mean age of 58.5 ± 16.3 years (range: 16-81 years). In this study, the most causes of corneal ulcer or perforation were immunologic causes (54.5%). After TEKIL procedure, global integrity was achieved in all cases. No immune rejection or perforation was detected. The mean BCVA improved from 0.17 ± 0.20 preoperatively to 0.27 ± 0.25 postoperatively at the final follow-up (t = 2.095, P = 0.052). The postoperative BCVA improved in 12 eyes (54.5%) and maintained in nine eyes (40.9%). Vision function successfully maintained in all eyes (100%). In three cases, corneal ulcers were treated by reoperation of TEKIL at 3 months after the initial surgery for the reason that the residual corneal thickness was <250 μm.
conclusionsTEKIL seems to be an effective treatment for corneal ulcer and perforation in the condition of emergency and donor shortage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.