Evidence map›Paper›PMID 27452864›Full record

ArticleVaccine2016

Strain-dependent and distinctive T-cell responses to HIV antigens following immunisation of mice with differing chimpanzee adenovirus vaccine vectors.

S Herath, A Le Heron, S Colloca, S Patterson, R Tatoud, J Weber, G Dickson

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Non-Human Primate-Derived Adenoviruses for Future Use as Oncolytic Agents?International journal of molecular sciences · 2020
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

S HerathSchool of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK.
A Le HeronSchool of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK.
S CollocaReiThera Srl, Viale Citta d'Europa 679, 00144 Rome, Italy.
S PattersonDepartment of Immunology, Imperial College London, London, UK.
R TatoudDepartment of Immunology, Imperial College London, London, UK.
J WeberDepartment of Immunology, Imperial College London, London, UK.
G DicksonSchool of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK. Electronic address: G.Dickson@rhul.ac.uk.
Imperial College London · GBRoyal Holloway University of London · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

In vivo vaccination studies are conventionally conducted in a single mouse strain with results, only reflecting responses to a single immunogenetic background. We decided to examine the immune response to an HIV transgene (gag, pol and nef fusion protein) in 3 strains of mice (CBA, C57BL/6 and BALB/c) to determine the spectrum of responses and in addition to determine whether the serotype of the adenoviral vector used (ChAd3 and ChAd63) impacted the outcome of response. Our results demonstrated that all three strains of mice responded to the transgene and that the magnitude of responses were different between the strains. The C57BL/6 strain showed the lowest range of responses compared to the other strains and, very few responses were seen to the same peptide pool in all three strains of mice. In CBA and BALB/c mice there were significant differences in IFNγ production dependent on the adenoviral vector used. Our results suggest that employing a single strain of mouse may underestimate the efficacy and efficiency of vaccine products.

Indexed as

Immunogenicity, VaccineAdenoviridaeAIDS VaccinesAnimalsFemalegag Gene Products, Human Immunodeficiency VirusHaplotypesHIV AntigensInterferon-gammaMice, Inbred BALB CMice, Inbred C57BLMice, Inbred CBAnef Gene Products, Human Immunodeficiency VirusPan troglodytespol Gene Products, Human Immunodeficiency VirusT-LymphocytesAIDS Vaccinesgag Gene Products, Human Immunodeficiency VirusHIV AntigensInterferon-gammanef Gene Products, Human Immunodeficiency Viruspol Gene Products, Human Immunodeficiency VirusHIVIFNγImmunologyMouseVaccine

Identifiers

PMID27452864
PMCPMC4978701
OpenAlexW2492615637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.