ArticleScientific reports2016
Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
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- Mechanisms in Graves Eye Disease: Apoptosis as the End Point of Insulin-Like Growth Factor 1 Receptor Inhibition.Thyroid : official journal of the American Thyroid Association · 2022Article
- Insights Into the Links Between Proteostasis and Aging FromFrontiers in aging · 2022Review
- Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation.Nature communications · 2021Article
- Meep, a Novel Regulator of Insulin Signaling, Supports Development and Insulin Sensitivity via Maintenance of Protein Homeostasis inG3 (Bethesda, Md.) · 2020Article
- Dietary Amino Acids Impact LRRK2-Induced Neurodegeneration in Parkinson's Disease Models.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Ageing, metabolism and the intestine.EMBO reports · 2020Review
- Diverse biological processes coordinate the transcriptional response to nutritional changes in a Drosophila melanogaster multiparent population.BMC genomics · 2020Article
- Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production.Aging cell · 2020Article
- Evolution of ageing as a tangle of trade-offs: energy versus function.Proceedings. Biological sciences · 2019Article
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- A Complex Relationship between Immunity and Metabolism in Drosophila Diet-Induced Insulin Resistance.Molecular and cellular biology · 2018Article
- Effect of young exosomes injected in aged mice.International journal of nanomedicine · 2018Article
- A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance.Molecular systems biology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Down-regulation of insulin/insulin-like growth factor signaling (IIS) can increase lifespan in C. elegans, Drosophila and mice. In C. elegans, reduced IIS results in down-regulation of translation, which itself can extend lifespan. However, the effect of reduced IIS on translation has yet to be determined in other multicellular organisms. Using two long-lived IIS models, namely Drosophila lacking three insulin-like peptides (dilp2-3,5(-/-)) and mice lacking insulin receptor substrate 1 (Irs1(-/-)), and two independent translation assays, polysome profiling and radiolabeled amino acid incorporation, we show that reduced IIS lowers translation in these organisms. In Drosophila, reduced IIS decreased polysome levels in fat body and gut, but reduced the rate of protein synthesis only in the fat body. Reduced IIS in mice decreased protein synthesis rate only in skeletal muscle, without reducing polysomes in any tissue. This lowered translation in muscle was independent of Irs1 loss in the muscle itself, but a secondary effect of Irs1 loss in the liver. In conclusion, down-regulation of translation is an evolutionarily conserved response to reduced IIS, but the tissues in which it occurs can vary between organisms. Furthermore, the mechanisms underlying lowered translation may differ in mice, possibly associated with the complexity of the regulatory processes.
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