Evidence map›Paper›PMID 27452272›Full record

ArticleScientific reports2016

Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8(+) T-cell frequencies in a macaque AIDS model.

Hiroshi Ishii, Saori Matsuoka, Takushi Nomura, Midori Nakamura, Teiichiro Shiino, Yuko Sato, Naoko Iwata-Yoshikawa, Hideki Hasegawa, Kazuta Mizuta, Hiromi Sakawaki and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Env-independent protection of intrarectal SIV challenge by vaccine induction of Gag/Vif-specific CD8Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Hiroshi IshiiAIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Saori MatsuokaAIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Takushi NomuraAIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Midori NakamuraAIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Teiichiro ShiinoAIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Yuko SatoDepartment of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Naoko Iwata-YoshikawaDepartment of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Hideki HasegawaDepartment of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Kazuta MizutaInstitute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.
Hiromi SakawakiInstitute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.
Tomoyuki MiuraInstitute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.
Yoshio KoyanagiInstitute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.
Taeko K NaruseDepartment of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Akinori KimuraDepartment of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Tetsuro MatanoAIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
National Institute of Infectious Diseases · JPKyoto University · JPTokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Virus-specific CD8(+) T cells exert strong suppressive pressure on human/simian immunodeficiency virus (HIV/SIV) replication. These responses have been intensively examined in peripheral blood mononuclear cells (PBMCs) but not fully analyzed in lymph nodes (LNs), where interaction between CD8(+) T cells and HIV/SIV-infected cells occurs. Here, we investigated target antigen specificity of CD8(+) T cells in LNs in a macaque AIDS model. Analysis of virus antigen-specific CD8(+) T-cell responses in the inguinal LNs obtained from twenty rhesus macaques in the chronic phase of SIV infection showed an inverse correlation between viral loads and frequencies of CD8(+) T cells with CD28(+) CD95(+) central memory phenotype targeting the N-terminal half of SIV core antigen (Gag-N). In contrast, analysis of LNs but not PBMCs revealed a positive correlation between viral loads and frequencies of CD8(+) T cells with CD28(-)CD95(+) effector memory phenotype targeting the N-terminal half of SIV envelope (Env-N), soluble antigen. Indeed, LNs with detectable SIV capsid p27 antigen in the germinal center exhibited significantly lower Gag-N-specific CD28(+) CD95(+) CD8(+) T-cell and higher Env-N-specific CD28(-)CD95(+) CD8(+) T-cell responses than those without detectable p27. These results imply that core and envelope antigen-specific CD8(+) T cells show different patterns of interactions with HIV/SIV-infected cells.

Indexed as

Acquired Immunodeficiency SyndromeAnimalsAntigens, ViralCD8-Positive T-LymphocytesDisease Models, AnimalGene Products, envGerminal CenterImmunologic MemoryLymph NodesMacacaMacaca mulattaSimian Immunodeficiency VirusViral LoadAntigens, ViralGene Products, env

Identifiers

PMID27452272
PMCPMC4958968
OpenAlexW2502576321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.