ArticleScientific reports2016
Proteomics of hot-wet and cold-dry temperaments proposed in Iranian traditional medicine: a Network-based Study.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- An insight to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis; evidence from high-throughput data integration and meta-analysis.Retrovirology · 2019Pooled it
- Traditional, complementary and alternative medicine in children constipation: a systematic review.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019Pooled it
- Investigating the relationship between innate temperament and the occurrence of radiotherapy-induced dermatitis and its treatment with Iranian medicine products.Archives of dermatological research · 2025Article
- Promoting planetary health and well-being for all: harnessing indigenous knowledges for health with traditional, complementary and integrative health systems.Frontiers in medicine · 2025Review
- Evaluation of relationship between memory and temperament in 18-28 years old students.Caspian journal of internal medicine · 2024Article
- The Network between Heart and Liver from the View of Persian Medicine Versus Conventional Medicine.Galen medical journal · 2023Article
- IrGO: Iranian traditional medicine General Ontology and knowledge base.Journal of biomedical semantics · 2021Article
- Association of temperament with genetic polymorphisms inMolecular biology research communications · 2021Article
- The Value of 'Traditionality': The Epistemological and Ethical Significance of Non-western Alternatives in Science.Science and engineering ethics · 2021Article
- Hot and Cold Theory: Evidence in Systems Biology.Advances in experimental medicine and biology · 2021Article
- Unsupervised Learning and Multipartite Network Models: A Promising Approach for Understanding Traditional Medicine.Frontiers in pharmacology · 2020Review
- UNaProd: A Universal Natural Product Database forEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Predicting Meridian in Chinese traditional medicine using machine learning approaches.PLoS computational biology · 2019Article
- A systematic survey of centrality measures for protein-protein interaction networks.BMC systems biology · 2018Article
- Reliability and validity assessment of gastrointestinal dystemperaments questionnaire: a novel scale in Persian traditional medicine.Electronic physician · 2018Article
- Identification and Analysis of Rice Yield-Related Candidate Genes by Walking on the Functional Network.Frontiers in plant science · 2018Article
- Association of glutathione S-transferase M1 and T1 polymorphisms and temperament.Molecular biology research communications · 2017Article
- Historical root of precision medicine: an ancient concept concordant with the modern pharmacotherapy.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2017Article
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3 authors.
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Abstract
Lack of molecular biology evidence has led clinical success of alternative and complementary medicine (CAM) to be marginalized. In turn, a large portion of life Science researchers could not communicate and help to develop therapeutic potential laid in these therapeutic approaches. In this study, we began to quantify descriptive classification theory in one of the CAM branches i.e. Iranian traditional medicine (ITM). Using proteomic tools and network analysis, the expressed proteins and their relationships were studied in mitochondrial lysate isolated from PBMCs from two different temperaments i.e. Hot-wet (HW) and Cold-dry (CD). The 82% of the identified proteins are over- or under-represented in distinct temperaments. Also, our result showed the different protein-protein interaction networks (PPIN) represented in these two temperaments using centrality and module finding analysis. Following the gene ontology and pathway enrichment analysis, we have found enriched biological terms in each group which are in conformity with the physiologically known evidence in ITM. In conclusion, we argued that the network biology which naturally consider life at the system level along with the different omics data will pave the way toward explicit delineation of the CAM activities.
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