ArticleJournal of the American Heart Association2016
Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study.
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18citing papers in PubMed, 1 pooled it
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effects of SGLT2 inhibitors on cardiovascular outcomes in patients with stage 3/4 CKD: A meta-analysis.PloS one · 2022Pooled it
- Association of cholesterol, high-density lipoprotein, and glucose (CHG) index with chronic kidney disease in Chinese community adults: findings from the REACTION study.Frontiers in nutrition · 2026Article
- Blood pressure variability is associated with the occurrence of diabetic microangiopathy in type 2 diabetes mellitus: a cross-sectional study.European journal of medical research · 2025Article
- Is Lipid a Missing Link Between Renal Function and Diabetes Risk? Insights from a Mediation Analysis Based on the Cohort Study.Journal of multidisciplinary healthcare · 2025Article
- Waist-to-hip ratio as a contributor associated with higher atherosclerotic cardiovascular disease risk assessment in patients with diabetes: a cross-sectional study.BMC cardiovascular disorders · 2024Article
- Trajectories of atherosclerotic cardiovascular disease risk scores as a predictor for incident chronic kidney disease.BMC nephrology · 2024Article
- Prospective bidirectional associations between depression and chronic kidney diseases.Scientific reports · 2022Article
- The prevalence and predictors of cardiovascular diseases in Kherameh cohort study: a population-based study on 10,663 people in southern Iran.BMC cardiovascular disorders · 2022Article
- Nontraditional risk factors in chronic kidney disease: correlation between creatinine clearance, Framingham risk score, endothelial dysfunction, and inflammation.The Egyptian journal of internal medicine · 2022Article
- Negative Risk Markers for Cardiovascular Risk Evaluation in Chinese Adults.Frontiers in cardiovascular medicine · 2022Article
- Association between atherosclerotic cardiovascular diseases risk and renal outcome in patients with type 2 diabetes mellitus.Renal failure · 2021Article
- Circulating microRNA-194 levels in Chinese patients with diabetic kidney disease: a case-control study.Therapeutic advances in endocrinology and metabolism · 2021Article
- Association Between Age at Diagnosis of Type 2 Diabetes and Cardiovascular Diseases: A Nationwide, Population-Based, Cohort Study.Frontiers in endocrinology · 2021Article
- Early-Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study.Journal of the American Heart Association · 2020Observational
- Cardiovascular and type 2 diabetes morbidity and all-cause mortality among diverse chronic inflammatory disorders.Heart (British Cardiac Society) · 2017Observational
- Red blood cell distribution width as a marker of cerebral infarction in hemodialysis patients.Renal failure · 2017Article
- Gender-specific association of decreased estimated glomerular filtration rate and left vertical geometry in the general population from rural Northeast China.BMC cardiovascular disorders · 2017Article
- Effects of Low-Protein Diet on lipid and anthropometric profiles of patients with chronic kidney disease on conservative management.Jornal brasileiro de nefrologiaArticle
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Authors and funding
41 authors at 20 institutions in 2 countries.
Jieli LuState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Yiming MuChinese People's Liberation Army General Hospital, Beijing, China.
Qing SuXinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Lixin ShiAffiliated Hospital of Guiyang Medical College, Guiyang, China.
Chao LiuJiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
Jiajun ZhaoShandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
Lulu ChenUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qiang LiThe Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Tao YangThe First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
Li YanSun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Qin WanThe Affiliated Hospital of Luzhou Medical College, Luzhou, China.
Shengli WuKaramay Municipal People's Hospital, Xinjiang, China.
Yan LiuThe First Hospital of Jilin University, Changchun, China.
Guixia WangThe First Hospital of Jilin University, Changchun, China.
Zuojie LuoThe First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xulei TangThe First Hospital of Lanzhou University, Lanzhou, China.
Gang ChenFujian Provincial Hospital, Fujian Medical University, Fuzhou, China.
Yanan HuoJiangxi People's Hospital, Nanchang, China.
Zhengnan GaoDalian Municipal Central Hospital, Dalian, China.
Zhen YeZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Youmin WangThe First Affiliated Hospital of Anhui Medical University, Hefei, China.
Guijun QinThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Huacong DengThe First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xuefeng YuTongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Feixia ShenThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Li ChenQilu Hospital of Shandong University, Jinan, China.
Liebin ZhaoState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Jichao SunState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Wanwan SunState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Tiange WangState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Rui DuState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Lin LinState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Meng DaiState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Yu XuState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Min XuState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Yufang BiState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Shenghan LaiJohns Hopkins University School of Medicine, Baltimore, MD.
Donghui LiDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Weiqing WangState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China wqingw61@163.com.
Guang NingState Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
REACTION Study Group
Shanghai Jiao Tong University · CNJiangsu Province Hospital · CNJilin University · CNAnhui Medical University · CNDalian Municipal Central Hospital · CNFirst Affiliated Hospital of Chongqing Medical University · CNFirst Affiliated Hospital of Wenzhou Medical University · CNFirst Affiliated Hospital of Zhengzhou University · CNFujian Medical University · CNGuangxi Medical University · CNHuazhong University of Science and Technology · CNJiangxi Provincial People's Hospital · CNJohns Hopkins University · USKaramay Central Hospital · CNLanzhou University · CNNanyang Medical College · CNPeople's Liberation Army No. 150 Hospital · CNQilu Hospital of Shandong University · CNSecond Affiliated Hospital of Harbin Medical University · CNShandong Provincial Hospital · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease (CKD) increases cardiovascular disease (CVD) risk. However, the association of mildly reduced kidney function with CVD risk is unclear. METHODS AND
resultsThis study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10-year Framingham risk for coronary heart disease (CHD), and 10-year risk of atherosclerotic cardiovascular diseases (ASCVD) in 239 832 participants from the baseline of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study. With an interviewer-assisted questionnaire, we collected information on CVD, including reported CHD, stroke, or myocardial infarction. Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation was used to calculate eGFR. Compared with individuals with normal eGFR (≥90 mL/min per 1.73 m(2)), those with decreased eGFR (75-89, 60-74, and <60 mL/min per 1.73 m(2)) had higher risk of prevalent obesity, diabetes mellitus, hypertension, and dyslipidemia in both men and women (P for trend all <0.001). Moreover, a significantly higher 10-year Framingham risk for CHD and 10-year risk for ASCVD was observed in both men and women with mildly decreased eGFR (60-89 mL/min per 1.73 m(2)).
conclusionsEven mildly reduced eGFR (under 90 mL/min per 1.73 m(2)) is associated with elevated 10-year Framingham risk for CHD and 10-year ASCVD risk among Chinese adults.
Indexed as
Asian PeopleAdultAgedCardiovascular DiseasesChinaCoronary DiseaseDiabetes MellitusDyslipidemiasFemaleHumansHypertensionMaleMiddle AgedMyocardial InfarctionObesityPrevalenceatherosclerotic cardiovascular diseasescardiovascular diseasesestimated glomerular filtration rateFramingham Risk Scorereduced kidney function
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