Evidence map›Paper›PMID 27451359›Full record

ReviewInternational journal for parasitology2017

Recent insights into humoral immunity targeting Plasmodium falciparum and Plasmodium vivax malaria.

Michelle J Boyle, Linda Reiling, Faith H Osier, Freya J I Fowkes

Abstract readReview
In one paragraph

Review in International journal for parasitology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michelle J BoyleBurnet Institute for Medical Research and Public Health, Melbourne, Victoria 3004, Australia; Menzies School of Medical Research, Darwin, Northern Territory 0810, Australia. Electronic address: mboyle@burnet.edu.au.
Linda ReilingBurnet Institute for Medical Research and Public Health, Melbourne, Victoria 3004, Australia.
Faith H OsierKEMRI Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.
Freya J I FowkesBurnet Institute for Medical Research and Public Health, Melbourne, Victoria 3004, Australia; Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria 3004, Australia; Department of Infectious Diseases, Monash University, Melbourne, Victoria 3004, Australia.

Funding

Medical Research Council MR/L00450X/1Medical Research Council MR/M003906/1Wellcome Trust 089833Wellcome Trust 203077
6 · The paper itself

Abstract

Recent efforts in malaria control have led to marked reductions in malaria incidence. However, new strategies are needed to sustain malaria elimination and eradication and achieve the World Health Organization goal of a malaria-free world. The development of highly effective vaccines would contribute to this goal and would be facilitated by a comprehensive understanding of humoral immune responses targeting Plasmodium falciparum and Plasmodium vivax malaria. New tools are required to facilitate the identification of vaccine candidates and the development of vaccines that induce functional and protective immunity. Here we discuss recent published findings, and unpublished work presented at the 2016 Molecular Approaches to Malaria conference, that highlight advancements in understanding humoral immune responses in the context of vaccine development. Highlights include the increased application of 'omics' and 'Big data' platforms to identify vaccine candidates, and the identification of novel functions of antibody responses that mediate protection. The application of these strategies and a global approach will increase the likelihood of rapid development of highly efficacious vaccines.

Indexed as

Immunity, HumoralAntibodies, ProtozoanHumansMalaria, FalciparumMalaria VaccinesMalaria, VivaxAntibodies, ProtozoanMalaria VaccinesComplementImmunityMalariaMicroarrayPhagocytosisPlasmodium falciparumPlasmodium vivaxVaccine

Identifiers

PMID27451359
PMCPMC7004821

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.