ArticleJournal of neurology, neurosurgery, and psychiatry2016
The contribution of lesion location to upper limb deficit after stroke.
Article in Journal of neurology, neurosurgery, and psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Variability in stroke motor outcome is explained by structural and functional integrity of the motor system.Scientific reports · 2018Trial
- Functional reorganization of the contralesional precentral gyrus following acute subcortical ischemic stroke and its association with gene expression profile.Journal of neuroengineering and rehabilitation · 2026Article
- Enhanced treatment of ischemic stroke by scutellarin loaded Angiopep-2-modified milk exosomes via multiple pathological pathways regulation.Journal of nanobiotechnology · 2026Article
- Vascular Health and Cutaneous Sensation are Predictive of Upper Limb Bone Loss in People with Stroke: A 2-Year Longitudinal Study.Calcified tissue international · 2026Article
- Corticospinal Tract Displacement: A Novel Imaging Marker for Arm Recovery in Patients with Acute Hypertensive Intracerebral Hemorrhage.AJNR. American journal of neuroradiology · 2025Article
- Lesion location changes the association between brain excitability and the performance of a short-term visuomotor adaptation task post-stroke.Brain communications · 2025Article
- Cerebellar Atrophy and Language Processing in Chronic Left-Hemisphere Stroke.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Data-driven biomarkers better associate with stroke motor outcomes than theory-based biomarkers.Brain communications · 2024Article
- Lesion-specific cortical activation following sensory stimulation in patients with subacute stroke.Journal of neuroengineering and rehabilitation · 2023Article
- Data-driven biomarkers outperform theory-based biomarkers in predicting stroke motor outcomes.bioRxiv : the preprint server for biology · 2023Article
- Predicting Motor Outcomes Using Atlas-Based Voxel Features of Post-Stroke Neuroimaging: A Scoping Review.Neurorehabilitation and neural repair · 2023Article
- Functional MRI evaluation of hyperbaric oxygen therapy effect on hand motor recovery in a chronic post-stroke patient: a case report and physiological discussion.Frontiers in neurology · 2023Article
- The predictive value of lesion and disconnectome loads for upper limb motor impairment after stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Periinfarct rewiring supports recovery after primary motor cortex stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Sensorimotor, Attentional, and Neuroanatomical Predictors of Upper Limb Motor Deficits and Rehabilitation Outcome after Stroke.Neural plasticity · 2021Article
- Dynamic Neural Network Changes Revealed by Voxel-Based Functional Connectivity Strength in Left Basal Ganglia Ischemic Stroke.Frontiers in neuroscience · 2020Article
- Abnormally reduced primary motor cortex output is related to impaired hand function in chronic stroke.Journal of neurophysiology · 2018Article
- Interhemispheric connectivity of primary sensory cortex is associated with motor impairment after stroke.Scientific reports · 2018Article
- PREP2: A biomarker-based algorithm for predicting upper limb function after stroke.Annals of clinical and translational neurology · 2017Article
- Brain regions important for recovery after severe post-stroke upper limb paresis.Journal of neurology, neurosurgery, and psychiatry · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundMotor deficit after stroke is related to regional anatomical damage.
objectiveTo examine the influence of lesion location on upper limb motor deficit in chronic patients with stroke.
methodsLesion likelihood maps were created from T1-weighted structural MRI in 33 chronic patients with stroke with either purely subcortical lesions (SC, n=19) or lesions extending to any of the cortical motor areas (CM, n=14). We estimated lesion likelihood maps over the whole brain and applied multivoxel pattern analysis to seek the contribution weight of lesion likelihood to upper limb motor deficit. Among 5 brain regions of interest, the brain region with the greatest contribution to motor deficit was determined for each subgroup.
resultsThe corticospinal tract was most likely to be damaged in both subgroups. However, while damage in the corticospinal tract was the best indicator of motor deficit in the SC patients, motor deficit in the CM patients was best explained by damage in brain areas activated during handgrip.
conclusionsQuantification of structural damage can add to models explaining motor outcome after stroke, but assessment of corticospinal tract damage alone is unlikely to be sufficient when considering patients with stroke with a wide range of lesion topography.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.