ArticleNeurobiology of learning and memory2016
Contextual fear conditioning induces differential alternative splicing.
Article in Neurobiology of learning and memory, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Alcohol and fear conditioning produce strain-specific changes in the dorsal hippocampal transcriptome of adolescent C57BL/6J and DBA/2J mice.Alcohol, clinical & experimental research · 2024Article
- The lncRNA Snhg11, a new candidate contributing to neurogenesis, plasticity, and memory deficits in Down syndrome.Molecular psychiatry · 2024Article
- Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation.Nature communications · 2023Article
- The lncRNA Snhg11, a new candidate contributing to neurogenesis, plasticity and memory deficits in Down syndrome.Research square · 2023Article
- Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion.Cell death & disease · 2023Article
- Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation.bioRxiv : the preprint server for biology · 2023Article
- Memory consolidation in honey bees is enhanced by down-regulation ofFrontiers in molecular neuroscience · 2023Article
- Hippocampal neurons' cytosolic and membrane-bound ribosomal transcript profiles are differentially regulated by learning and subsequent sleep.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Dynamically expressed single ELAV/Hu orthologue elavl2 of bees is required for learning and memory.Communications biology · 2021Article
- Primary cilia are required for the persistence of memory and stabilization of perineuronal nets.iScience · 2021Article
- BET bromodomains as novel epigenetic targets for brain health and disease.Neuropharmacology · 2020Review
- Translational changes induced by acute sleep deprivation uncovered by TRAP-Seq.Molecular brain · 2020Article
- MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus.Molecular brain · 2020Article
- The CBP KIX domain regulates long-term memory and circadian activity.BMC biology · 2020Article
- Alcohol Causes Lasting Differential Transcription inGenetics · 2020Article
- Article
- Focus on females: A less biased approach for studying strategies and mechanisms of memory.Current opinion in behavioral sciences · 2018Article
- Experience-dependent neural plasticity, learning, and memory in the era of epitranscriptomics.Genes, brain, and behavior · 2018Review
- Nuclease integrated kinase super assemblies (NiKs) and their role in RNA processing.Current genetics · 2018Review
- Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism.Science signaling · 2018Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
The process of memory consolidation requires transcription and translation to form long-term memories. Significant effort has been dedicated to understanding changes in hippocampal gene expression after contextual fear conditioning. However, alternative splicing by differential transcript regulation during this time period has received less attention. Here, we use RNA-seq to determine exon-level changes in expression after contextual fear conditioning and retrieval. Our work reveals that a short variant of Homer1, Ania-3, is regulated by contextual fear conditioning. The ribosome biogenesis regulator Las1l, small nucleolar RNA Snord14e, and the RNA-binding protein Rbm3 also change specific transcript usage after fear conditioning. The changes in Ania-3 and Las1l are specific to either the new context or the context-shock association, while the changes in Rbm3 occur after context or shock only. Our analysis revealed novel transcript regulation of previously undetected changes after learning, revealing the importance of high throughput sequencing approaches in the study of gene expression changes after learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.