Evidence map›Paper›PMID 27450948›Full record

ArticleJournal of the American Medical Directors Association2016

Muscle Weakness Is Associated With Diabetes in Older Mexicans: The Mexican Health and Aging Study.

Mark D Peterson, Ryan McGrath, Peng Zhang, Kyriakos S Markides, Soham Al Snih, Rebeca Wong

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Medical Directors Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

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  11. Handgrip Strength and Health in Aging Adults.Sports medicine (Auckland, N.Z.) · 2018
    Article
  12. Observational
  13. Muscle Strength and Functional Limitations: Preserving Function in Older Mexican Americans.Journal of the American Medical Directors Association · 2018
    Article
  14. Article
  15. Article
  16. Article
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  18. The Association Between Muscle Weakness and Incident Diabetes in Older Mexican Americans.Journal of the American Medical Directors Association · 2017
    Observational
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Mark D PetersonDepartment of Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI. Electronic address: mdpeterz@med.umich.edu.
Ryan McGrathDepartment of Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI.
Peng ZhangDepartment of Surgery, University of Michigan, Ann Arbor, MI.
Kyriakos S MarkidesDepartment of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX.
Soham Al SnihDivision of Rehabilitation Sciences/School of Health Professions, Department of Internal Medicine/Division of Geriatrics, University of Texas Medical Branch, Galveston, TX.
Rebeca WongSealy Center on Aging; Preventive Medicine & Community Health; WHO/PAHO Collaborating Center on Aging and Health, University of Texas Medical Branch, Galveston, TX.
The University of Texas Medical Branch at Galveston · USUniversity of Michigan–Ann Arbor · US

Funding

UTMB OAIC Research Education Component (REC)P30AG024832 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI JAMES S. GOODWIN, MD, MELISSA M. MORROW · 2005 to 2026
$26.7M
The Mexican Health and Aging Study - IIR01AG018016 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Rebeca Wong · 1999 to 2026
$22.6M
Research BaseP30DK092926 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARY ELLEN MICHELE HEISLER, ADESUWA B OLOMU · 2011 to 2026
$10.0M
Secondary Muscle Pathology & Metabolic Dysregulation in Adult with Cerebral PalsyK01HD074706 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, MARK D · 2013 to 2017
$605k
Developing Personalized Treatment for Diabetes Through Novel Imaging MethodsK01DK106296 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, PENG · 2016 to 2018
$465k
NIA NIH HHS P30 AG024832NIA NIH HHS R01 AG018016NICHD NIH HHS K01 HD074706NIDDK NIH HHS K01 DK106296NIDDK NIH HHS P30 DK092926
6 · The paper itself

Abstract

backgroundThe risk of cardiovascular problems due to diabetes mellitus is highest among older Mexicans, and yet what remains to be determined is the association between muscle weakness and diabetes in this population. Therefore, the purpose of this study was to determine the association between muscle strength and diabetes among Mexican adults greater than 50 years of age.

designCross-sectional.

settingNational sample of households in both urban and rural areas.

participantsA subsample of 1841 individuals aged 50 years and older was included from the 2012 Mexican Health and Aging Study. MEASUREMENTS: Strength was assessed using a hand-held dynamometer, and the single largest reading from either hand was normalized to body mass (normalized grip strength [NGS]). Conditional inference tree analyses were used to identify sex-specific NGS weakness thresholds. Linear regression was used to examine the association between NGS and HbA1c, and logistic regression was used to assess the association between weakness and risk of diabetes (HbA1c ≥ 6.5% [≥48 mmol/mol]), after controlling for age, sex, and waist circumference.

resultsNGS was inversely associated with HbA1c (β = -1.56; P < .001). Optimal sex-specific NGS weakness thresholds to detect diabetes were ≤0.46 and ≤0.30 for men and women, respectively. Weakness was associated with significantly increased odds of diabetes (odds ratio, 1.69; 95% confidence interval, 1.37-2.10), even after adjusting for age, sex, and waist circumference.

conclusionsNGS was robustly associated with diabetes and other cardiometabolic risk factors in older Mexicans. This simple screen may serve as a valuable tool to identify adults that are at risk for negative health consequences or early mortality and who might benefit from lifestyle interventions to reduce risk.

Indexed as

Diabetes MellitusMexican AmericansMuscle WeaknessAgedAgingCross-Sectional StudiesFemaleHand StrengthHumansInsulin ResistanceLogistic ModelsMaleMiddle AgedMuscle Strength DynamometeragingdiabetesepidemiologyInsulin resistancemuscle weakness

Identifiers

PMID27450948
PMCPMC5039066
OpenAlexW2481256663

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.