ArticleJournal of neuroscience methods2016
An automated rat single pellet reaching system with high-speed video capture.
Article in Journal of neuroscience methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A paradigm for skilled forelimb reaching by head-restrained mice.bioRxiv : the preprint server for biology · 2026Article
- Paw Preference in Rats Across Tests, Strains, Sex, and Age: A PRISMA-Compliant Systematic Review and Meta-Analysis.bioRxiv : the preprint server for biology · 2026Article
- Rigorous Validation of Paw Preference Using Three Complementary Behavioral Assays in Sprague Dawley Rats.bioRxiv : the preprint server for biology · 2026Article
- Repeated tDCS at Clinically Relevant Field Intensity Can Boost Concurrent Motor Learning in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Skilled reaching test for shoulder function assessment in a rat model of rotator cuff tear: a pilot study.BMC musculoskeletal disorders · 2024Article
- AutoRG: An automatized reach-to-grasp platform technology for assessing forelimb motor function, neural circuit activation, and cognition in rodents.Journal of neuroscience methods · 2023Article
- A dystonia mouse model with motor and sequencing deficits paralleling human disease.Behavioural brain research · 2022Article
- Dopamine neuron stimulation induces context-dependent abnormal involuntary movements in healthy rats.iScience · 2022Article
- Evaluation of animal models and methods for assessing shoulder function after rotator cuff tear: A systematic review.Journal of orthopaedic translation · 2021Review
- Precisely timed dopamine signals establish distinct kinematic representations of skilled movements.eLife · 2020Article
- Behavioral testing in animal models of spinal cord injury.Experimental neurology · 2020Review
- Aberrant features of in vivo striatal dynamics in Parkinson's disease.Journal of neuroscience research · 2019Review
- Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories.Journal of visualized experiments : JoVE · 2019Article
- Automated Forelimb Tasks for Rodents: Current Advantages and Limitations, and Future Promise.Neurorehabilitation and neural repair · 2019Article
- Chronic stability of single-channel neurophysiological correlates of gross and fine reaching movements in the rat.PloS one · 2019Article
- Directional Reaching for Water as a Cortex-Dependent Behavioral Framework for Mice.Cell reports · 2018Article
- The Knob Supination Task: A Semi-automated Method for Assessing Forelimb Function in Rats.Journal of visualized experiments : JoVE · 2017Article
- Automated Assessment of Endpoint and Kinematic Features of Skilled Reaching in Rats.Frontiers in behavioral neuroscience · 2017Article
- Article
- Buspirone Dose-Response on Facilitating Forelimb Functional Recovery in Cervical Spinal Cord Injured Rats.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundSingle pellet reaching is an established task for studying fine motor control in which rats reach for, grasp, and eat food pellets in a stereotyped sequence. Most incarnations of this task require constant attention, limiting the number of animals that can be tested and the number of trials per session. Automated versions allow more interventions in more animals, but must be robust and reproducible. NEW
methodOur system automatically delivers single reward pellets for rats to grasp with their forepaw. Reaches are detected using real-time computer vision, which triggers video acquisition from multiple angles using mirrors. This allows us to record high-speed (>300 frames per second) video, and trigger interventions (e.g., optogenetics) with high temporal precision. Individual video frames are triggered by digital pulses that can be synchronized with behavior, experimental interventions, or recording devices (e.g., electrophysiology). The system is housed within a soundproof chamber with integrated lighting and ventilation, allowing multiple skilled reaching systems in one room.
resultsWe show that rats acquire the automated task similarly to manual versions, that the task is robust, and can be synchronized with optogenetic interventions. COMPARISON WITH EXISTING
methodsExisting skilled reaching protocols require high levels of investigator involvement, or, if ad libitum, do not allow for integration of high-speed, synchronized data collection.
conclusionThis task will facilitate the study of motor learning and control by efficiently recording large numbers of skilled movements. It can be adapted for use with modern neurophysiology, which demands high temporal precision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.