ReviewSchizophrenia research2016
The dysconnection hypothesis (2016).
Review in Schizophrenia research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 279 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
279 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Aberrant cortical-subcortical-cerebellar connectivity in resting-state fMRI as an imaging marker of schizophrenia and psychosis: a systematic review of data-driven whole-brain functional connectivity analyses.Frontiers in neuroimaging · 2025Pooled it
- Pooled it
- A meta-analysis and systematic review of single vs. multimodal neuroimaging techniques in the classification of psychosis.Molecular psychiatry · 2023Pooled it
- fMRI connectivity as a biomarker of antipsychotic treatment response: A systematic review.NeuroImage. Clinical · 2023Pooled it
- Cerebellar stimulation in schizophrenia: A systematic review of the evidence and an overview of the methods.Frontiers in psychiatry · 2022Pooled it
- Peripheral magnetic stimulation effects on brain activity in older adults with schizophrenia - a randomized controlled pilot study.Frontiers in psychiatry · 2026Trial
- Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin.Molecular psychiatry · 2024Trial
- Higher-order functional brain networks and anterior cingulate glutamate + glutamine (Glx) in antipsychotic-naïve first episode psychosis patients.Translational psychiatry · 2024Trial
- Effects of Exercise on Structural and Functional Brain Patterns in Schizophrenia-Data From a Multicenter Randomized-Controlled Study.Schizophrenia bulletin · 2024Trial
- Trial
- Lower multisensory temporal acuity in individuals with high schizotypal traits: a web-based study.Scientific reports · 2022Trial
- Mapping topological abnormalities in cortical similarity networks to schizophrenia-associated gene expression.Dialogues in clinical neuroscience · 2026Article
- Rethinking schizophrenia: insights from genomics and implications for research.Molecular psychiatry · 2026Review
- Neural Oscillatory Signatures of Predictive Processing in Visual Statistical Learning.Annals of the New York Academy of Sciences · 2026Article
- Cognitive impairment and associated white matter organization abnormalities across the illness course of schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Co-expression-based models improve eQTL predictions for transcriptome-wide association studies and highlight new schizophrenia-associated genes.Nature genetics · 2026Article
- Does ChatGPT need a psychiatrist? Similarities between human psychopathology and errors in large language models.NPP - digital psychiatry and neuroscience · 2026Review
- Large-scale brain dynamics are organized by a directional coordination hierarchy.bioRxiv : the preprint server for biology · 2026Article
- Loss of regional theta differentiation in TMS-EEG response marks network dysfunction in psychosis risk.Translational psychiatry · 2026Article
- Network-based analysis of differential white matter connectivity in major depressive disorder with and without comorbid anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
219 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Twenty years have passed since the dysconnection hypothesis was first proposed (Friston and Frith, 1995; Weinberger, 1993). In that time, neuroscience has witnessed tremendous advances: we now live in a world of non-invasive neuroanatomy, computational neuroimaging and the Bayesian brain. The genomics era has come and gone. Connectomics and large-scale neuroinformatics initiatives are emerging everywhere. So where is the dysconnection hypothesis now? This article considers how the notion of schizophrenia as a dysconnection syndrome has developed - and how it has been enriched by recent advances in clinical neuroscience. In particular, we examine the dysconnection hypothesis in the context of (i) theoretical neurobiology and computational psychiatry; (ii) the empirical insights afforded by neuroimaging and associated connectomics - and (iii) how bottom-up (molecular biology and genetics) and top-down (systems biology) perspectives are converging on the mechanisms and nature of dysconnections in schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.