ReviewAnnals of the New York Academy of Sciences2016
Cyanide and the human brain: perspectives from a model of food (cassava) poisoning.
Review in Annals of the New York Academy of Sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome.Molecular medicine (Cambridge, Mass.) · 2020Pooled it
- A Colorimetric Sensor for Cyanide Ion Detection Using a Poly(TCDA)-Based Material Sensor.ACS omega · 2026Article
- Assessment of the physicochemical characteristics of by-products of cassava processing and their effects on biodiversity.Environmental monitoring and assessment · 2025Article
- Children's cognitive impairment associated with cassava cyanide in Democratic Republic of the Congo: Burden of disease.PLOS global public health · 2024Article
- Alteration in Cerebral Metabolism in a Rodent Model of Acute Sub-lethal Cyanide Poisoning.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023Article
- DNA methylation patterns associated with konzo in Sub-Saharan Africa.Clinical epigenetics · 2022Article
- CRISPR-Cas9-mediated knockout ofFrontiers in plant science · 2022Article
- The gut microbiome in konzo.Nature communications · 2021Observational
- Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and its Implication for Medicine.Biomedicines · 2020Review
- Preclinical and clinical research on the toxic and neurological effects of cassava (Manihot esculenta Crantz) consumption.Metabolic brain disease · 2020Review
- Chronic consumption of cassava juice induces cellular stress in rat substantia nigra.Iranian journal of basic medical sciences · 2020Article
- Outbreak of Cyanide Poisoning Caused by Consumption of Cassava Flour - Kasese District, Uganda, September 2017.MMWR. Morbidity and mortality weekly report · 2019Article
- Cognitive and motor performance in Congolese children with konzo during 4 years of follow-up: a longitudinal analysis.The Lancet. Global health · 2017Article
- Complex Metal Ions: Neuropsychiatric and Imaging Features.The Journal of neuropsychiatry and clinical neurosciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Threats by fundamentalist leaders to use chemical weapons have resulted in renewed interest in cyanide toxicity. Relevant insights may be gained from studies on cyanide mass intoxication in populations relying on cyanogenic cassava as the main source of food. In these populations, sublethal concentrations (up to 80 μmol/l) of cyanide in the blood are commonplace and lead to signs of acute toxicity. Long-term toxicity signs include a distinct and irreversible spastic paralysis, known as konzo, and cognition deficits, mainly in sequential processing (visual-spatial analysis) domains. Toxic culprits include cyanide (mitochondrial toxicant), thiocyanate (AMPA-receptor chaotropic cyanide metabolite), cyanate (protein-carbamoylating cyanide metabolite), and 2-iminothiazolidine-4-carboxylic acid (seizure inducer). Factors of susceptibility include younger age, female gender, protein-deficient diet, and, possibly, the gut functional metagenome. The existence of uniquely exposed and neurologically affected populations offers invaluable research opportunities to develop a comprehensive understanding of cyanide toxicity and test or validate point-of-care diagnostic tools and treatment options to be included in preparedness kits in response to cyanide-related threats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.