Evidence map›Paper›PMID 27450578›Full record

ReviewNeuroscience and biobehavioral reviews2016

Chronic methamphetamine self-administration disrupts cortical control of cognition.

Aurelien Bernheim, Ronald E See, Carmela M Reichel

Open access · greenAbstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. The Top-Down of Prefrontal Cortex to the Hippocampus Glutamatergic Pathway Regulates Reward Memory of Methamphetamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  17. Midlife and Older Age Methamphetamine Poisoning Deaths in Hawai'i.Hawai'i journal of health & social welfare · 2024
    Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Aurelien BernheimDepartment of Neurosciences, Medical University of South Carolina, Charleston, SC, USA.
Ronald E SeeDepartment of Psychology, Westmont College, Santa Barbara, CA, USA.
Carmela M ReichelDepartment of Neurosciences, Medical University of South Carolina, Charleston, SC, USA. Electronic address: reichel@musc.edu.
Medical University of South Carolina · USWestmont College · US

Funding

Corticostriatal Neuroplasticity and Cognition in Methamphetamine AddictionR01DA033049 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SCOFIELD, MICHAEL DAVID · 2012 to 2022
$3.4M
NIDA NIH HHS R01 DA033049
6 · The paper itself

Abstract

Methamphetamine (meth) is one of the most abused substances worldwide. Chronic use has been associated with repeated relapse episodes that may be exacerbated by cognitive impairments during drug abstinence. Growing evidence demonstrates that meth compromises prefrontal cortex activity, resulting in persisting attentional and memory impairments. After summarizing recent studies of meth-induced cognitive dysfunction using a translationally relevant model of self-administered meth, this review emphasizes the cortical brain changes contributing to cognitive dysregulation during abstinence. Finally, we propose the use of cognitive enhancers during abstinence that may promote a drug-free state by reversing cortical dysfunction linked with prolonged meth abuse.

Indexed as

CognitionAmphetamine-Related DisordersHumansMemory DisordersMethamphetamineSelf AdministrationMethamphetamineAddictionAttentionCognitive deficitsGlutamateMethamphetamineObject recognitionPerirhinalPrefrontal

Identifiers

PMID27450578
PMCPMC5030184
OpenAlexW2485545500

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.