Evidence map›Paper›PMID 27450399›Full record

ReviewMedical science monitor basic research2016

Cardiac Hypertrophy: An Introduction to Molecular and Cellular Basis.

Mostafa Samak, Javid Fatullayev, Anton Sabashnikov, Mohamed Zeriouh, Bastian Schmack, Mina Farag, Aron-Frederik Popov, Pascal M Dohmen, Yeong-Hoon Choi, Thorsten Wahlers and 1 more

Abstract readReview
In one paragraph

Review in Medical science monitor basic research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Raspberry protective role in inflammatory diseases: An overview.Iranian journal of basic medical sciences · 2026
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Engineering Nanoparticles and Bioscaffolds for Targeted microRNA Delivery in Cardiovascular Regeneration-A Comprehensive Review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  13. Article
  14. Logic-based machine learning predicts how escitalopram attenuates cardiomyocyte hypertrophy.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. SGLT2 inhibitors: how do they affect the cardiac cells.Molecular and cellular biochemistry · 2025
    Review
  16. International journal of molecular sciences · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mostafa SamakDepartment of Cardiothoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, London, United Kingdom.
Javid FatullayevDepartment of Cardiothoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, London, United Kingdom.
Anton SabashnikovDepartment of Cardiothoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, London, United Kingdom.
Mohamed ZeriouhDepartment of Cardiothoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, London, United Kingdom.
Bastian SchmackDepartment of Cardiothoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, London, United Kingdom.
Mina FaragDepartment of Cardiac Surgery, Heart and Marfan Center - University of Heidelberg, Heidelberg, Germany.
Aron-Frederik PopovDepartment of Cardiothoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, London, United Kingdom.
Pascal M DohmenDepartment of Cardiovascular Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Yeong-Hoon ChoiDepartment of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
Thorsten WahlersDepartment of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
Alexander WeymannDepartment of Cardiac Surgery, Heart and Marfan Center - University of Heidelberg, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ventricular hypertrophy is an ominous escalation of hemodynamically stressful conditions such as hypertension and valve disease. The pathophysiology of hypertrophy is complex and multifactorial, as it touches on several cellular and molecular systems. Understanding the molecular background of cardiac hypertrophy is essential in order to protect the myocardium from pathological remodeling, or slow down the destined progression to heart failure and cardiomyopathy. In this review we highlight the most important molecular aspects of cardiac hypertrophic growth in light of the currently available published research data.

Indexed as

AnimalsCardiomegalyHumansMyocardium

Identifiers

PMID27450399
PMCPMC4976758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.