Evidence map›Paper›PMID 27450201›Full record

ReviewTrends in neurosciences2016

Enteric Neuronal Regulation of Intestinal Inflammation.

Kara Gross Margolis, Michael D Gershon

Open access · greenAbstract readReview
In one paragraph

Review in Trends in neurosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 106 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Neuroimmune Interactions in the Intestine.Annual review of immunology · 2024
    Review
  9. Article
  10. Review
  11. Review
  12. The S100B Protein: A Multifaceted Pathogenic Factor More Than a Biomarker.International journal of molecular sciences · 2023
    Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. The Shaggy Dog Story of Enteric Signaling: Serotonin, a Molecular Megillah.Advances in experimental medicine and biology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kara Gross MargolisDepartment of Pediatrics, Columbia University College of Physicians and Surgeons, 620 West 168th Street, New York, NY 10032, USA.
Michael D GershonDepartment of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, 650 West 168th Street, New York, NY 10032, USA. Electronic address: mdg4@cumc.columbia.edu.
Columbia University · US

Funding

MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENTR01NS015547 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GERSHON, MICHAEL D, MARGOLIS, KARA GROSS · 1985 to 2022
$7.2M
VZV in the enteric nervous system: pathogenesis and consequencesR01DK093094 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MICHAEL D GERSHON, Anne A. Gershon · 2011 to 2026
$5.9M
Enteric Neuronal Development as a Determinant of Intestinal InflammationK08DK093786 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARGOLIS, KARA GROSS · 2013 to 2017
$781k
NIDDK NIH HHS K08 DK093786NIDDK NIH HHS R01 DK093094NINDS NIH HHS R01 NS015547
6 · The paper itself

Abstract

Recent research has highlighted the importance of the two-way interaction between the nervous and immune systems. This interaction is particularly important in the bowel because of the unique properties of this organ. The lumen of the gut is lined by a very large but remarkably thin surface that separates the body from the enteric microbiome. Immune defenses against microbial invasion are thus well developed and neuroimmune interactions are important in regulating and integrating these defenses. Important concepts in the phylogeny of neuroimmunity, enteric neuronal and glial regulation of immunity, changes that occur in the enteric nervous system during inflammation, the fundamental role of serotonin (5-HT) in enteric neuroimmune mechanisms, and future perspectives are reviewed.

Indexed as

AnimalsEnteric Nervous SystemHumansInflammationIntestinal DiseasesMicrobiotaNeuroimmunomodulationSerotoninSerotonin5-HTenteric gliaenteric nervous systeminflammatory bowel diseasemicrobiomeneuroimmunityserotonin

Identifiers

PMID27450201
PMCPMC5002370
OpenAlexW2485663801

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.