Evidence map›Paper›PMID 27450014›Full record

ArticleTuberculosis (Edinburgh, Scotland)2016

Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis.

Michael G Whitfield, Elizabeth M Streicher, Tania Dolby, John A Simpson, Samantha L Sampson, Paul D Van Helden, Annelies Van Rie, Robin M Warren

Abstract read
In one paragraph

Article in Tuberculosis (Edinburgh, Scotland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Resistance to pyrazinamide inJournal of clinical tuberculosis and other mycobacterial diseases · 2024
    Article
  3. Phenotypic and genotypic characterization ofFrontiers in microbiology · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Migrations do not modify Mycobacterium tuberculosis resistance rates: a 20-year retrospective study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Pyrazinamide Susceptibility andAntimicrobial agents and chemotherapy · 2017
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael G WhitfieldSA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa.
Elizabeth M StreicherSA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa.
Tania DolbyNational Health Laboratory Service, Cape Town, South Africa.
John A SimpsonNational Health Laboratory Service, Cape Town, South Africa.
Samantha L SampsonSA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa.
Paul D Van HeldenSA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa.
Annelies Van RieUniversity of North Carolina at Chapel Hill, North Carolina, USA; Epidemiology for Global Health Institute, Department of Epidemiology and Social Medicine, Faculty of Medicine, University of Antwerp, Antwerp, Belgium.
Robin M WarrenSA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa. Electronic address: rw1@sun.ac.za.

Funding

Optimizing the impact of Xpert MTB/RIF on treatment outcomes of drug resistant TBR01AI099026 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI VAN RIE, ANNELIES T.A. · 2012 to 2014
$1.6M
NIAID NIH HHS R01 AI099026
6 · The paper itself

Abstract

Pyrazinamide resistance is largely unknown in the spectrum of drug resistant phenotypes. We summarize data on PZA resistance in clinical isolates from South Africa. PZA DST should be performed when considering its inclusion in treatment of patients with rifampicin-resistant TB or MDR-TB.

Indexed as

Drug Resistance, Multiple, BacterialAntitubercular AgentsGenotypeHumansMicrobial Sensitivity TestsMutationMycobacterium tuberculosisPhenotypePrevalencePyrazinamideSouth AfricaTuberculosis, Multidrug-ResistantAntitubercular AgentsPyrazinamideDNA sequencingMycobacterium tuberculosispncA genePyrazinamide

Identifiers

PMID27450014
PMCPMC4963978

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.