Evidence map›Paper›PMID 27449812›Full record

ArticlePhysiological reports2016

Characterization of oscillatory changes in hippocampus and amygdala after deep brain stimulation of the infralimbic prefrontal cortex.

Ana Cervera-Ferri, Vicent Teruel-Martí, Moises Barceló-Molina, Joana Martínez-Ricós, Aina Luque-García, Sergio Martínez-Bellver, Albert Adell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Biomarkers for Deep Brain Stimulation in Animal Models of Depression.Neuromodulation : journal of the International Neuromodulation Society · 2022
    Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ana Cervera-FerriNeuronal Circuits Laboratory, Department of Human Anatomy and Embriology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain.
Vicent Teruel-MartíNeuronal Circuits Laboratory, Department of Human Anatomy and Embriology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain.
Moises Barceló-MolinaNeuronal Circuits Laboratory, Department of Human Anatomy and Embriology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain Instituto de Investigación Sanitaria La Fe, Valencia, 46026, Spain.
Joana Martínez-RicósNeuronal Circuits Laboratory, Department of Human Anatomy and Embriology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain.
Aina Luque-GarcíaNeuronal Circuits Laboratory, Department of Human Anatomy and Embriology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain Instituto de Investigación Sanitaria La Fe, Valencia, 46026, Spain.
Sergio Martínez-BellverNeuronal Circuits Laboratory, Department of Human Anatomy and Embriology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain Department of Cell Biology and Parasitology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain.
Albert AdellInstitute of Biomedicine and Biotechnology of Cantabria, IBBTEC (CSIC University of Cantabria), Santander, 39011, Spain albert.adell@unican.es.
Universitat de València · ESInstituto de Investigación Sanitaria La Fe · ESUniversidad de Cantabria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep brain stimulation (DBS) is a new investigational therapy that has generated positive results in refractory depression. Although the neurochemical and behavioral effects of DBS have been examined, less attention has been paid to the influence of DBS on the network dynamics between different brain areas, which could contribute to its therapeutic effects. Herein, we set out to identify the effects of 1 h DBS in the infralimbic cortex (IL) on the oscillatory network dynamics between hippocampus and basolateral amygdala (BLA), two regions implicated in depression and its treatment. Urethane-anesthetized rats with bilaterally implanted electrodes in the IL were exposed to 1 h constant stimulation of 130 Hz of frequency, 60 μA of constant current intensity and biphasic pulse width of 80 μsec. After a period of baseline recording, local field potentials (LFP) were recorded with formvar-insulated stainless steel electrodes. DBS of the IL increased the power of slow wave (SW, <1.5 Hz) and theta (3-12 Hz) frequencies in the hippocampus and BLA Furthermore, IL DBS caused a precise coupling in different frequency bands between both brain structures. The increases in SW band synchronization in hippocampus and BLA after DBS suggest that these changes may be important for the improvement of depressive behavior. In addition, the augmentation in theta synchrony might contribute to improvement in emotional and cognitive processes.

Indexed as

Brain WavesDeep Brain StimulationElectroencephalographyAmygdalaAnimalsBehavior, AnimalHippocampusMaleNeural PathwaysPrefrontal CortexRats, WistarSignal Processing, Computer-AssistedTime FactorsAntidepressantbrain oscillationslocal field potentialmodulatory indexmutual information

Identifiers

PMID27449812
PMCPMC4962070
OpenAlexW2500652009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.