ReviewNeurogenetics2017
Circular RNAs-one of the enigmas of the brain.
Review in Neurogenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- Sphingomyelin regulates the transcriptional machinery in nuclear lipid microdomains.Communications biology · 2025Article
- Circular RNAs Variously Participate in Coronary Atherogenesis.Current issues in molecular biology · 2023Review
- Article
- CircOAS3 Regulates Keratinocyte Proliferation and Psoriatic Inflammation by Interacting with Hsc70 via the JNK/STAT3/NF-κB Signaling Pathway.Inflammation · 2022Article
- First Genome of Rock LizardGenes · 2022Article
- Genomic Variants and Multilevel Regulation ofJournal of cardiovascular development and disease · 2021Review
- Non-coding RNAs: the extensive and interactive regulators of the blood-brain barrier permeability.RNA biology · 2021Review
- A Narrative Review of Circular RNAs in Brain Development and Diseases of Preterm Infants.Frontiers in pediatrics · 2021Review
- Silencing CircHIPK3 Sponges miR-93-5p to Inhibit the Activation of Rac1/PI3K/AKT Pathway and Improves Myocardial Infarction-Induced Cardiac Dysfunction.Frontiers in cardiovascular medicine · 2021Article
- Circular RNAs Sparkle in the Diagnosis and Theranostics of Hepatocellular Carcinoma.Frontiers in genetics · 2020Review
- Circular RNA 0001313 Knockdown Suppresses Non-Small Cell Lung Cancer Cell Proliferation and Invasion via the microRNA-452/HMGB3/ERK/MAPK Axis.International journal of general medicine · 2020Article
- Circular RNAs: Functions and Prospects in Glioma.Journal of molecular neuroscience : MN · 2019Review
- Noncoding RNAs in neurodegeneration.Nature reviews. Neuroscience · 2017Review
- Circular RNAs: A Novel Player in Development and Disease of the Central Nervous System.Frontiers in cellular neuroscience · 2017Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) provide a new and relatively unexplored class of noncoding RNAs that are predominantly found in mammalian cells. In this review, we present the latest data regarding the structural organization, possible mechanisms of synthesis, and functions of circRNAs. These transcripts were isolated as an RNA fraction that was resistant to RNase R treatment, which selectively destroys the linear forms of RNA molecules. circRNAs are encoded by orthologous genes in different organisms and show tissue- and organ-specific expression. Currently, the biogenesis and functional properties of circRNAs remain unclear; transcripts of this class, however, remain highly promising targets of research. Some of them have been ascribed the function of "molecular sponges" that can absorb microRNAs, RNA-binding proteins, and small nuclear RNAs. circRNAs are often formed from the RNA portions of protein-coding genes in the course of alternative splicing. Some features of the circRNAs of mammals were demonstrated using 11 circRNAs of the human sphingomyelin synthase 1 gene (SGMS1), which were discovered by us in the brain. These circRNAs consist mainly of portions of the multi-exon 5' untranslated region (5'UTR) of the SGMS1 gene and include one to five exons. The synthesis of circRNAs may be new, previously unknown, function of the multi-exon 5'UTR of genes. This feature is most clearly manifested in the brain, where the level of circRNAs is significantly higher.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.