Evidence map›Paper›PMID 27449761›Full record

ArticleLa Radiologia medica2016

Comparison of the effect of region-of-interest methods using gadoxetic acid-enhanced MR imaging with diffusion-weighted imaging on staging hepatic fibrosis.

Ying Ding, Shengxiang Rao, Li Yang, Caizhong Chen, Mengsu Zeng

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in La Radiologia medica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  8. [Value of gadoxetate disodium-enhanced magnetic resonance on hepatobiliary phase T1 mapping for predicting liver injury].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ying DingDepartment of Radiology, Zhongshan Hospital Fudan University, Shanghai Medical Imaging Institute, No 138, Fenglin Road, Xuhui District, Shanghai, 200032, China.
Shengxiang RaoDepartment of Radiology, Zhongshan Hospital Fudan University, Shanghai Medical Imaging Institute, No 138, Fenglin Road, Xuhui District, Shanghai, 200032, China. raoxray@163.com.
Li YangDepartment of Radiology, Zhongshan Hospital Fudan University, Shanghai Medical Imaging Institute, No 138, Fenglin Road, Xuhui District, Shanghai, 200032, China.
Caizhong ChenDepartment of Radiology, Zhongshan Hospital Fudan University, Shanghai Medical Imaging Institute, No 138, Fenglin Road, Xuhui District, Shanghai, 200032, China.
Mengsu ZengDepartment of Radiology, Zhongshan Hospital Fudan University, Shanghai Medical Imaging Institute, No 138, Fenglin Road, Xuhui District, Shanghai, 200032, China.
Shanghai Medical College of Fudan University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the utility of T1 mapping on gadoxetic acid-enhanced MRI and DWI for staging liver fibrosis and assess the influence of ROI positioning on interobserver variability, T1 relaxation time and ADC value.

methodsThis retrospective study was approved by the institutional review board and included 150 patients (mean age 58 years old; 91 men and 59 women). Liver fibrosis stages (S) were histopathologically determined. T1 relaxation time and ADC value of liver were measured by three distinct ROI protocols (the whole left lobe liver, the whole right lobe liver and the individual ROIs). T1 relaxation time measurements were compared with ADC values according to S scores. Interobserver variability for the T1 relaxation times and ADC values by the three distinct ROI protocols was analyzed by calculating the ICC.

resultsT1 relaxation time measurements by the three distinct ROI protocols on severe fibrosis stage were significantly higher than the relative values on mild fibrosis stage. The mean ADC values on severe fibrosis stage showed no significantly different when measured by means of the whole right lobe liver (p = 0.057) and the individual ROIs (p = 0.10), compared with the relative values on mild fibrosis stage. AUCs of T1 relaxation time and ADC value by the means of the three distinct ROI protocols were 0.614, 0.676, 0.677 and 0.656, 0.585, 0.575 for identification of severe fibrosis stage. The interobserver reproducibility was excellent for measuring the right lobe liver T1 relaxation time and the individual ROIs T1 relaxation time (ICC 0.814, 0.883, respectively).

conclusionsT1 relaxation time measurements by means of the three distinct ROI protocols on gadoxetic acid-enhanced MR imaging were a potential biomarker in staging of hepatic fibrosis, which were more accuracy than DWI-ADC measurements. The more reproducible results were obtained when measuring T1 relaxation time of the whole right lobe liver and the individual ROIs.

Indexed as

Gadolinium DTPAContrast MediaDiffusion Magnetic Resonance ImagingFemaleHumansImage EnhancementLiver CirrhosisMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsRetrospective StudiesContrast MediaGadolinium DTPAgadolinium ethoxybenzyl DTPAApparent diffusion coefficientGadoxetic acidLiver fibrosisMagnetic resonance imagingObserver variationT1 relaxation time

Identifiers

PMID27449761
OpenAlexW2504850270

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.