Evidence map›Paper›PMID 27449502›Full record

ReviewImmunologic research2017

Rituximab therapy for IgA-vasculitis with nephritis: a case series and review of the literature.

Roberta Fenoglio, Carla Naretto, Bruno Basolo, Giacomo Quattrocchio, Michela Ferro, Paola Mesiano, Giulietta Beltrame, Dario Roccatello

Open access · greenAbstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Immune abnormalities in IgA nephropathy.Clinical kidney journal · 2023
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes.International journal of molecular sciences · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. Adult-Onset Immunoglobulin A Vasculitis.ACG case reports journal · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Roberta FenoglioNephrology and Dialysis Unit, Center of Research of Immunopathology and Rare Diseases, Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Giovanni Bosco Hospital and University of Turin, Turin, Italy.
Carla NarettoNephrology and Dialysis Unit, Center of Research of Immunopathology and Rare Diseases, Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Giovanni Bosco Hospital and University of Turin, Turin, Italy.
Bruno BasoloNephrology and Dialysis Unit, Center of Research of Immunopathology and Rare Diseases, Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Giovanni Bosco Hospital and University of Turin, Turin, Italy.
Giacomo QuattrocchioNephrology and Dialysis Unit, Center of Research of Immunopathology and Rare Diseases, Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Giovanni Bosco Hospital and University of Turin, Turin, Italy.
Michela FerroNephrology and Dialysis Unit, Center of Research of Immunopathology and Rare Diseases, Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Giovanni Bosco Hospital and University of Turin, Turin, Italy.
Paola MesianoNephrology and Dialysis Unit, Center of Research of Immunopathology and Rare Diseases, Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Giovanni Bosco Hospital and University of Turin, Turin, Italy.
Giulietta BeltrameNephrology and Dialysis Unit, Center of Research of Immunopathology and Rare Diseases, Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Giovanni Bosco Hospital and University of Turin, Turin, Italy.
Dario RoccatelloNephrology and Dialysis Unit, Center of Research of Immunopathology and Rare Diseases, Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Giovanni Bosco Hospital and University of Turin, Turin, Italy. dario.roccatello@unito.it.
University of Turin · ITOspedale San Giovanni Bosco · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Henoch-Schonlein purpura, also called IgA-vasculitis, is a systemic small vessels vasculitis with immunoglobulin A1-dominant immune deposits. The optimal treatment remains controversial. Because IgA-vasculitis is characterized by leukocyte infiltration of the blood vessel walls along with immunoglobulin A deposition, and because glucocorticosteroids inhibit inflammatory processes, early administration of glucocorticosteroids has been postulated to be effective, but this indication remains controversial. Immunosuppressive agents (azathioprine, cyclophosphamide, cyclosporine, mycophenolate) have been used in combination with glucocorticosteroids without definitive evidence of effectiveness. The efficacy of rituximab in adult IgA-vasculitis has been reported in few cases. We described a monocentric experience on the use of rituximab in adult IgA-vasculitis with biopsy-proven nephritis. The patients achieved a complete remission of nephritis and syndromic manifestations, and no patients experienced adverse reactions. These data have been compared with the limited literature nowadays available.

Indexed as

AdultAgedFemaleHumansIgA VasculitisImmunosuppressive AgentsMaleMiddle AgedNephritisRituximabYoung AdultImmunosuppressive AgentsRituximabANCA-associated vasculitisB cell depletion therapyHenoch–Schonlein purpura nephritisHenoch–Schonlein treatmentIgA-vasculitisRituximab

Identifiers

PMID27449502
OpenAlexW2493243615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.