ArticleBreast cancer research and treatment2016
Race/ethnicity, genetic ancestry, and breast cancer-related lymphedema in the Pathways Study.
Article in Breast cancer research and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is axillary web syndrome a risk factor for breast cancer-related lymphedema of the upper extremity? A systematic review and meta-analysis.Breast cancer research and treatment · 2024Pooled it
- Using Machine Learning to Predict Breast Cancer-Related Lymphedema Following Axillary Lymph Node Dissection.Annals of surgical oncology · 2026Article
- Breast Cancer-Related Lymphedema: A Common Challenge among Nigerian Breast Cancer Survivors.Breast care (Basel, Switzerland) · 2026Article
- Examining the Interrelationships of Lymphedema with Pain, Physical Function, and Demographic and Medical Variables in Women with Breast Cancer and Pain.Clinical breast cancer · 2026Article
- Socioeconomic and ethnic disparities in breast cancer-related lymphedema and quality-of-life after immediate lymphatic reconstruction.Breast cancer research and treatment · 2025Article
- A phenomenological study of women with breast cancer-related lymphedema using the healthcare system.The British journal of occupational therapy · 2025Article
- Metformin Use and Risk of Breast Cancer-Related Lymphedema: A Retrospective Analysis.Journal of the American College of Surgeons · 2025Article
- Long-Term Outcomes of Lymphedema After Immediate Lymphatic Reconstruction Following Axillary Lymph Node Dissection.Annals of surgical oncology · 2025Article
- Disparities in Breast Cancer-related Lymphedema: A Systematic Review of Inequities and Barriers in Care.Plastic and reconstructive surgery. Global open · 2025Article
- Commonly Prescribed Chronic Pharmacological Medications as Risk Factors for Breast Cancer-Related Lymphedema: An Observational Retrospective Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Article
- The influence of non-cancer-related risk factors on the development of cancer-related lymphedema: a rapid review.Medical oncology (Northwood, London, England) · 2024Review
- Lymphatic pain in breast cancer survivors: An overview of the current evidence and recommendations.Women and children nursing · 2024Article
- Lymphedema self-assessment among endometrial cancer survivors.Cancer causes & control : CCC · 2024Article
- Disparities in Breast Cancer Care-How Factors Related to Prevention, Diagnosis, and Treatment Drive Inequity.Healthcare (Basel, Switzerland) · 2024Review
- Comprehensive strategies in breast cancer-related lymphedema prevention: insights from a multifaceted program.Frontiers in oncology · 2024Article
- Feasibility and Clinical Utility of Prediction Models for Breast Cancer-Related Lymphedema Incorporating Racial Differences in Disease Incidence.JAMA surgery · 2023Article
- Clinical associations for traditional and complementary medicine use among norwegian cancer survivors in the seventh survey of the Tromsø study: a cross-sectional study.BMC complementary medicine and therapies · 2023Article
- Immediate lymphatic reconstruction for the prevention of breast cancer-related lymphedema: an experience highlighting the importance of lymphatic anatomy.Plastic and aesthetic research · 2023Article
- Article
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Authors and funding
12 authors.
Funding
Abstract
Breast cancer-related lymphedema (BCRL) is a serious chronic condition after breast cancer (BC) surgery and treatment. It is unclear if BCRL risk varies by race/ethnicity. In a multiethnic prospective cohort study of 2953 BC patients, we examined the association of self-reported BCRL status with self-reported race/ethnicity and estimated genetic ancestry. Hazard ratios (HR) and 95 % confidence intervals (CI) were calculated by multivariable Cox proportional hazards models, with follow-up starting 6 months post-BC diagnosis. Estimates were further stratified by body mass index (BMI). By 48 months of follow-up, 342 (11.6 %) women reported having BCRL. Younger age at BC diagnosis, higher BMI at baseline, and lower physical activity were associated with greater BCRL risk. African American (AA) women had a 2-fold increased risk of BCRL compared with White women (HR = 2.04; 95 % CI 1.35-3.08). African genetic ancestry was also associated with an increased risk (HR = 2.50; 95 % CI 1.43, 4.36). Both risks were attenuated but remained elevated after adjusting for known risk factors and became more pronounced when restricted to the nonobese women (adjusted HR = 2.31 for AA and HR = 3.70 for African ancestry, both p < 0.05). There was also evidence of increased BCRL risk with Hispanic ethnicity in the nonobese women. Nonobese AA women had a higher risk of BCRL than White women, which cannot be fully explained by known risk factors. This is the first large-scale, prospective study demonstrating differences in BCRL risk according to race/ethnicity as assessed by both self-report and genetic ancestry data, with a potential ancestry-obesity interaction.
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