Evidence map›Paper›PMID 27449472›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2016

A unified statistical model for the human electrocorticogram.

Giridhar P Kalamangalam, Mircea I Chelaru, Jeremy D Slater

Abstract read
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Giridhar P KalamangalamDepartment of Neurology, University of Texas Health Science Centre, Houston, TX, USA. Electronic address: Giridhar.P.Kalamangalam@uth.tmc.edu.
Mircea I ChelaruDepartment of Neurobiology, University of Texas Health Science Centre, Houston, TX, USA.
Jeremy D SlaterDepartment of Neurology, University of Texas Health Science Centre, Houston, TX, USA.

Funding

Advancing Diagnosis and Functional Localization in Focal Epilepsy with Oxygen-Enhanced MRIK23NS079900 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KALAMANGALAM, GIRIDHAR PADMANABHAN · 2012 to 2016
$982k
NINDS NIH HHS K23 NS079900
6 · The paper itself

Abstract

objectiveExtracellular field potentials (ECFs) generated in the cerebral cortex span a vast range of spatiotemporal scales. The process(es) leading to this large dynamic range remain debatable. Here we propose a novel statistical description of the amplitude spectrum of the human electrocorticogram (ECoG).

methodsSpectral analysis was performed on long-term recordings from epilepsy patients undergoing pre-surgical evaluation with intracranial electrodes. Amplitude spectra were fit with a multi-component Gaussian model on semi-logarithmic axes.

resultsThe Gaussian formulation provided excellent fits to the data. It also suggested how the changes accompanying the sleep-wake cycle and certain epileptiform transitions could be understood by variation in the parameters of the model.

conclusionsThe proposed continuum model synthesizes several previous observations regarding the statistical structure of the resting human ECoG. It offers a conceptual platform for understanding the EEG changes accompanying the sleep-wake cycle and pathologically hypersynchronous behaviour. SIGNIFICANCE: Statistical characterisation of the spectral distribution of field potentials yield insight into the cortico-cortical interactions that underlie the summated cortical ECFs comprising the ECoG. Such insight is relevant for a synoptic understanding of major state changes in the brain that are diagnosed in clinical practice by visual inspection of the ECoG.

Indexed as

Models, StatisticalAdultBrain MappingCerebral CortexElectrodes, ImplantedElectroencephalographyEpilepsyFemaleHumansMaleSleep StagesEEGEpilepsyLog normal distributionPower lawSynchronisation

Identifiers

PMID27449472
PMCPMC6377706

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.