SynthesisEquine veterinary journal2017
Heritability and prevalence of selected osteochondrosis lesions in yearling Thoroughbred horses.
Synthesis in Equine veterinary journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 41 citations in OpenAlex.
- Defining the Impact of Genetics on Equine Performance and Development of Orthopaedic Disease.Animals : an open access journal from MDPI · 2026Review
- Derivation of Equine Mesenchymal Stem/Stromal Cells from Induced Pluripotent Stem Cells via the Neural Crest Pathway and Characterisation by Immunophenotype and Tri-Lineage Differentiation.Animals : an open access journal from MDPI · 2026Article
- Heritability of sudden cardiac death in Thoroughbred racehorses.Equine veterinary journal · 2025Article
- Article
- Article
- Equine induced pluripotent stem cells are responsive to inflammatory cytokines before and after differentiation into musculoskeletal cell types.In vitro cellular & developmental biology. Animal · 2023Article
- SNP-Based Heritability of Osteochondrosis Dissecans in Hanoverian Warmblood Horses.Animals : an open access journal from MDPI · 2023Article
- Evaluation of the appearance of osteochondrosis lesions by two radiographic examinations in sport horses aged from 12 to 36 months.PloS one · 2023Article
- Osteochondrosis dissecans (OCD) in horses: hormonal and biochemical study (19 cases).Veterinary research forum : an international quarterly journal · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteochondrosis is considered multifactorial in origin, with factors such as nutrition, conformation, body size, trauma and genetics thought to contribute to its pathogenesis. Few studies have investigated the effects of genetic variability of osteochondrosis in Thoroughbreds.
objectivesTo describe the prevalence and genetic variability of a subset of osteochondrosis lesions in a group of Thoroughbred yearlings. STUDY
designRetrospective cohort study.
methodsRadiographs of 1962 Thoroughbred yearlings were retrieved from clinical records obtained between 2005 and 2013. Pedigree information was obtained from the Australian Stud Book. Osteochondrosis lesions were documented in selected joints and estimates of heritability were obtained by fitting linear mixed models in ASREML software.
resultsThe overall prevalence of osteochondrosis was 23%. Osteochondrosis was identified in 10% of stifle joints, 6% of hock joints and 8% of fetlock joints. The heritability estimates ranged from 0 to 0.21. The largest estimates were 0.10, 0.14, 0.16 and 0.21 for lesions of the distal intermediate ridge of the tibia, dorso-proximal proximal phalanx (P1), any stifle osteochondrosis, and lesions of the lateral trochlear ridge of the distal femur, respectively. Although calculated heritability estimates had high standard errors, meta-analyses combining the present results with published estimates were significant at 0.10, 0.17, 0.15 and 0.20 for stifle, tarsal, fetlock and these joints combined, respectively. In addition, there was a permanent environment attributable to the dam effect. MAIN LIMITATIONS: Inclusion criteria were based on radiographic findings in specific joints at a specific age range in Thoroughbreds.
conclusionsThe present results indicate that only a proportion of osteochondrosis in Thoroughbreds is heritable. The permanent environment effects of the dam were observed to have effects on some categories of osteochondrosis.
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