Evidence map›Paper›PMID 27448831›Full record

ArticleOphthalmology2016

Rectus Extraocular Muscle Size and Pulley Location in Concomitant and Pattern Exotropia.

Rui Hao, Soh Youn Suh, Alan Le, Joseph L Demer

Abstract read
In one paragraph

Article in Ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Age-related changes in the orbital pulley array of older Japanese adults with acquired exotropia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Surgical Dosing for V-Pattern Exotropia.American journal of ophthalmology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Inferior displacement of the lateral rectus muscle insertion in exotropia with mild V-pattern or vertical deviation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
  8. Article
  9. Article
  10. Comitant strabismus etiology: extraocular muscle integrity and central nervous system involvement-a narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Review
  11. Range of forced cyclorotation in superior oblique palsy and V-pattern strabismus.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  12. Article
  13. Article
  14. Inferior rectus displacement in heavy eye syndrome and sagging eye syndrome.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Article
  15. Normal Topography and Binocularity of the Superior Colliculus in Strabismus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  16. Incomitance and Eye Dominance in Intermittent Exotropia.Investigative ophthalmology & visual science · 2017
    Observational
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Rui HaoDepartment of Ophthalmology, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California; Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University, Peoples Republic of China.
Soh Youn SuhDepartment of Ophthalmology, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California.
Alan LeStein Eye Institute, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California.
Joseph L DemerDepartment of Ophthalmology, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California; Stein Eye Institute, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California; Department of Neurology, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California; Neuroscience Interdepartmental Program, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California; Bioengineering Interdepartmental Program, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California. Electronic address: jld@jsei.ucla.edu.
Doheny Eye Institute · USTianjin Medical University · CNUniversity of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERYR01EY008313 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOSEPH Louis DEMER · 1991 to 2026
$15.0M
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY008313
6 · The paper itself

Abstract

purposeTo determine whether rectus extraocular muscle (EOM) sizes and pulley locations contribute to exotropia, we used magnetic resonance imaging (MRI) to measure these factors in normal control participants and in patients with concomitant and pattern exotropia.

designProspective case-control study.

participantsNine patients with concomitant exotropia, 6 patients with pattern exotropia, and 21 orthotropic normal control participants.

methodsHigh-resolution surface-coil MRI scans were obtained in contiguous, quasicoronal planes. Rectus pulley locations were determined in oculocentric coordinates for central gaze, supraduction, and infraduction. Cross sections in 4 contiguous image planes were summed and multiplied by the 2-mm slice thickness to obtain horizontal rectus posterior partial volumes (PPVs).

main outcome measuresRectus pulley locations and horizontal rectus PPVs.

resultsRectus pulleys were located differently in patients with A-pattern, versus V- and Y-pattern, exotropia. The lateral rectus (LR) pulleys were displaced significantly superiorly, the medial rectus (MR) pulleys were displaced inferiorly, and the inferior rectus pulleys were displaced laterally in A-pattern exotropia. However, the array of all rectus pulleys was excyclorotated in V- and Y-pattern exotropia. The PPV of the medial rectus muscle was statistically subnormal by approximately 29% in concomitant, but not pattern, exotropia (P < 0.05). The ratio of the PPV of the LR relative to the MR muscles in concomitant exotropia was significantly greater than in control participants and those with pattern exotropia (P < 0.05).

conclusionsAbnormalities of EOMs and pulleys contribute differently in pattern versus concomitant exotropia. Abnormal rectus pulley locations derange EOM pulling directions that contribute to pattern exotropia, but in concomitant exotropia, pulley locations are normal, and relatively small medial rectus size reduces relative adducting force.

Indexed as

AdultCase-Control StudiesComputer SimulationExotropiaFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOculomotor MusclesProspective StudiesYoung Adult

Identifiers

PMID27448831
PMCPMC4995140
OpenAlexW2499126595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.