ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2016
Sympathetic cardiovascular and sudomotor functions are frequently affected in early multiple sclerosis.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07273292 (Autonomic Dysfunction in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis), which is not on this map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Autonomic Dysfunction in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis : A Comparative Study
Who cites it
30 citing papers in PubMed.
- Virtual EMO-Mind: Exploring the Benefits of Virtual Mindfulness for Heart Rate Variability and Emotional Skills in Young Students.Applied psychophysiology and biofeedback · 2026Article
- A Study on the Spectrum of Autonomic Dysfunction in Primary Central Nervous System Demyelinating Disorders in a Tertiary Care Center from Eastern India.Annals of Indian Academy of Neurology · 2026Article
- Don't miss the prodrome: neurogenic orthostatic hypotension as a window into multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Morphological and functional assessment of the vagus nerve in multiple sclerosis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Autonomic nervous system abnormalities in children with inflammatory bowel disease and irritable bowel syndrome: a comparative study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Review
- The Heart-Brain Interplay in Multiple Sclerosis from Pathophysiology to Clinical Practice: A Narrative Review.Journal of cardiovascular development and disease · 2023Review
- Impact of dysautonomic symptom burden on the quality of life in Neuromyelitis optica spectrum disorder patients.BMC neurology · 2023Article
- Heart rate variability and fatigue in MS: two parallel pathways representing disseminated inflammatory processes?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Review
- The pathophysiology of motor fatigue and fatigability in multiple sclerosis.Frontiers in neurology · 2022Review
- Acute Thermoregulatory and Cardiovascular Response to Submaximal Exercise in People With Multiple Sclerosis.Frontiers in immunology · 2022Article
- Unveiling the relationship between autonomic involvement, fatigue, and cognitive dysfunction in early relapsing-remitting multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Cardiac autonomic function in patients with early multiple sclerosis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Peripheral nervous system in multiple sclerosis-understanding the involvement via autonomic nervous system.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Evidence of Autonomic Dysfunction in Patients with Relapsing-Remitting Multiple Sclerosis: Heart Rate Variability and Cardiovascular Parameters.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021Article
- The association between the adrenergic hyperactivity and blood pressure values in people with multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- The diversity of neuronal phenotypes in rodent and human autonomic ganglia.Cell and tissue research · 2020Review
- Cardiac Autonomic Modulation Is Different in Terms of Clinical Variant of Multiple Sclerosis.Journal of clinical medicine · 2020Article
- Heart rate variability and pulmonary dysfunction in rats subjected to hemorrhagic shock.BMC cardiovascular disorders · 2020Article
- Cardiac Autonomic Dysfunction in Multiple Sclerosis: A Systematic Review of Current Knowledge and Impact of Immunotherapies.Journal of clinical medicine · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to determine the prevalence of autonomic dysfunction using the composite autonomic scoring scale (CASS) and heart rate variability (HRV) in patients with clinically isolated syndrome (CIS) and to correlate autonomic dysfunction with other measures of MS disease activity.
methodsCASS, HRV and plasma catecholamines during supine and tilted phase were performed in 104 CIS patients. MRI findings were analyzed for total number of lesions and the presence of brainstem and cervical spinal cord lesions.
resultsAutonomic dysfunction (CASS >1) was present in 59.8 % of patients, parasympathetic dysfunction in 5 %, sympathetic in 42.6 % and sudomotor in 32.7 % of patients. Patients with autonomic dysfunction on CASS had lower level of norepinephrine in the supine position compared to patients without autonomic dysfunction (1.06 ± 0.53 vs. 1.37 ± 0.86, p = 0.048). The CASS score showed positive correlation with s-HF (r = 0.226, p = 0.031), s-SDNN (r = 0.221, p = 0.035), t-HF (r = 0.225, p = 0.032), and t-HFnu (r = 0.216, p = 0.04), and a negative correlation with t-LF/HF (r = -0.218, p = 0.038). More patients with MRI brainstem lesions had a positive adrenergic index (p = 0.038). Patients with MRI brainstem lesions also had a lower t-SDNN (26.2 ± 14.2 vs. 32 ± 13.3, p = 0.036) and a lower t-LF (median 415.0 vs. 575.5, p = 0.018) compared to patients without these lesions. Patients with adrenergic index ≥1 had a significantly higher standing heart rate compared to patients with an adrenergic index of 0 (96 ± 13.5 vs. 90 ± 12, p = 0.032).
conclusionAutonomic (primarily sympathetic) dysfunction is present in a large proportion of early MS patients and it seems to be related to brainstem involvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.