ArticleBMC infectious diseases2016
Optimal use of plasma and urine BK viral loads for screening and predicting BK nephropathy.
Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Serum and urine nucleic acid screening tests for BK polyomavirus-associated nephropathy in kidney and kidney-pancreas transplant recipients.The Cochrane database of systematic reviews · 2024Pooled it
- The association between serum tacrolimus concentrations and BK viruria in kidney transplant recipients.Scientific reports · 2025Article
- Characterization ofViruses · 2024Article
- Evaluating the Efficiency of the Cobas 6800 System for BK Virus Detection in Plasma and Urine Samples.Diagnostics (Basel, Switzerland) · 2023Article
- Clinical and immunological characteristics for BK polyomavirus-associated nephropathy after kidney transplantation.Immunity, inflammation and disease · 2023Article
- Levels of donor-derived cell-free DNA and chemokines in BK polyomavirus-associated nephropathy.Clinical transplantation · 2022Article
- Genotypes and Variants of BKPyV in Organ Donors after Brain Death.International journal of molecular sciences · 2022Article
- Article
- BK Virus-Associated Nephropathy after Renal Transplantation.Pathogens (Basel, Switzerland) · 2021Review
- The 2018 Banff Working Group classification of definitive polyomavirus nephropathy: A multicenter validation study in the modern era.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Detection of Proximal Tubule Involvement by BK Polyomavirus in Kidney Transplant Recipients With Urinary Sediment Double-Immunostaining.Frontiers in immunology · 2020Article
- BK Virus Nephropathy: Prevalence, Impact and Management Strategies.International journal of nephrology and renovascular disease · 2020Review
- The Banff Working Group Classification of Definitive Polyomavirus Nephropathy: Morphologic Definitions and Clinical Correlations.Journal of the American Society of Nephrology : JASN · 2018Article
- Polyoma virus nephropathy in kidney transplantation.World journal of transplantation · 2017Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBK virus is a polyoma virus causing renal allograft nephropathy. Reduction of immunosuppression with the early recognition of significant BK viral loads in urine and plasma can effectively prevent BKV associated nephropathy (BKVN), however the optimal compartment and frequency of BK viral load measurement post renal transplantation are undetermined. Our purpose was to examine time to detection and viral loads in urine compared to plasma, and establish viral load cut-offs associated with histological BKVN.
methodsWe performed a retrospective analysis of the BKV screening frequency and compartment(s) of 277 adult renal transplant recipients (RTR).
resultsBKVN was histologically diagnosed in 17 (6.1 %) RTR. In cases where both urine and plasma were tested fortnightly for 6 months (n = 53), BKV was detected in the urine 29 days earlier than plasma. Fortnightly (n = 72) versus 3-monthly (n = 78) testing demonstrated that BKV was detected in the urine significantly earlier (median 63 versus 97 days, p = 0.001) and at a lower level (median 3.27 versus 6.71 log10 c/mL, p < 0.001) with more frequent testing, but this difference was not evident in plasma first detection (80 versus 95 days, p = 0.536) or first positive viral load (3.18 versus 3.30 log10 c/mL, p = 0.603). The optimum cut-off BK viral load for histological diagnosis of BKVN was 4.10 log10 c/mL for the first positive urine, 3.79 log10 c/mL for the first positive plasma, 9.24 log10 c/mL for the peak urine, and 4.53 log10 c/mL for the peak plasma.
conclusionsFrequent urinary BK viral load screening for the prevention of BKVN is suggested due to its high sensitivity and earlier detection.
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