Trial reportSleep medicine2016
Obstructive Sleep Apnea and Cognition in Parkinson's disease.
Trial report in Sleep medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Guidelines for Parkinson's disease management part II: consensus from the movement disorders scientific department of the Brazilian Academy of Neurology - non-motor symptoms.Arquivos de neuro-psiquiatria · 2025Guideline
- Prevalence and clinical aspects of obstructive sleep apnea in Parkinson disease: A meta-analysis.European journal of neurology · 2024Pooled it
- Polysomnographic Predictors of Sleep, Motor, and Cognitive Dysfunction Progression in Parkinson's Disease.Current neurology and neuroscience reports · 2022Pooled it
- Trial
- Stage-specific interactions among PLM, RBD, and OSAHS in parkinson's disease and MSA.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Associations between risk of obstructive sleep apnea and cognitive performance In Parkinson's disease: evidence from the Canadian Longitudinal Study on Aging.Sleep & breathing = Schlaf & Atmung · 2025Article
- Meta-analysis of the prevalence of obstructive sleep apnea and associated risk factors among Parkinson's disease.Sleep and biological rhythms · 2025Review
- Neuroprotective Effect of Melatonin on Sleep Disorders Associated with Parkinson's Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Effect of Sleep Disturbance on Cognitive Function in Elderly Individuals: A Prospective Cohort Study.Journal of personalized medicine · 2022Article
- Parkinson disease-associated cognitive impairment.Nature reviews. Disease primers · 2021Review
- Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease.Current neuropharmacology · 2021Review
- Sleep Issues in Parkinson's Disease and Their Management.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Obstructive Sleep Apnea in Neurodegenerative Disorders: Current Evidence in Support of Benefit from Sleep Apnea Treatment.Journal of clinical medicine · 2020Review
- Sleep in Parkinson's disease.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson's Disease.Frontiers in neuroscience · 2020Article
- The Neuropsychiatry of Parkinson Disease: A Perfect Storm.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Review
- PlasmaAnnals of clinical and translational neurology · 2019Article
- Obstructive Sleep Apnea and the Risk of Cognitive Decline in Older Adults.American journal of respiratory and critical care medicine · 2019Review
- Management Recommendations on Sleep Disturbance of Patients with Parkinson's Disease.Chinese medical journal · 2018Article
- Change in Cognition and Other Non-Motor Symptoms With Obstructive Sleep Apnea Treatment in Parkinson Disease.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveObstructive sleep apnea (OSA) is very common in Parkinson's disease (PD). OSA is known to affect patients' cognition. The present study assessed whether PD patients with OSA (PD + OSA) score lower on cognitive measures than those without OSA (PD - OSA). In addition, this study evaluated whether treating the OSA with continuous positive airway pressure (CPAP) in PD + OSA patients results in an improved cognitive functioning.
methodsEighty-six patients with PD underwent an overnight polysomnography screen for OSA and were administered the Mini-Mental Status Exam (MMSE) and the Montreal Cognitive Assessment (MoCA). This resulted in 38 patients with PD + OSA who were randomly assigned to receive either therapeutic CPAP for 6 weeks (n = 19) or placebo CPAP for three weeks followed by therapeutic CPAP for three weeks (n = 19). Intervention participants completed a neurocognitive battery at baseline and 3- and 6-week time-points.
resultsPatients with PD + OSA scored significantly lower than PD - OSA on the MMSE and MoCA after controlling for age, education, and PD severity. OSA was a significant predictor of cognition (MMSE p <0.01; MoCA p = 0.028).There were no significant changes between groups in cognition when comparing three weeks of therapeutic CPAP with 3 weeks of placebo CPAP. Comparisons between pre-treatment and 3-week post-therapeutic CPAP for the entire sample also revealed no significant changes on overall neuropsychological (NP) scores.
conclusionsFindings suggest that PD patients with OSA show worse cognitive functioning on cognitive screening measures than those without OSA. However, OSA treatment after three or six weeks of CPAP may not result in overall cognitive improvement in patients with PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.