ArticleIEEE transactions on bio-medical engineering2016
Electrical Stimulation of the Human Cerebral Cortex by Extracranial Muscle Activity: Effect Quantification With Intracranial EEG and FEM Simulations.
Article in IEEE transactions on bio-medical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Human hippocampal ripples coordinate planning sequences and compositional representations in neocortex.Nature neuroscience · 2026Article
- Sleep enhances gamma oscillations in the seizure onset zone and broadband activity in the irritative zone of focal cortical dysplasia.Epilepsia open · 2026Article
- Chewing modulates theta oscillation and functional connectivity of the frontocentral cortex in attention and working memory.Scientific reports · 2025Article
- FIRDA, refractory epilepsy, and SEEG-guided RF: A case report.Epilepsia open · 2023Article
- Identification and classification of pathology and artifacts for human intracranial cognitive research.NeuroImage · 2023Article
- A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations.Nature communications · 2022Review
- Article
- Food intake precipitates seizures in temporal lobe epilepsy.Scientific reports · 2021Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveElectric fields (EF) of approx. 0.2 V/m have been shown to be sufficiently strong to both modulate neuronal activity in the cerebral cortex and have measurable effects on cognitive performance. We hypothesized that the EF caused by the electrical activity of extracranial muscles during natural chewing may reach similar strength in the cerebral cortex and hence might act as an endogenous modality of brain stimulation. Here, we present first steps toward validating this hypothesis.
methodsUsing a realistic volume conductor head model of an epilepsy patient having undergone intracranial electrode placement and utilizing simultaneous intracranial and extracranial electrical recordings during chewing, we derive predictions about the chewing-related cortical EF strength to be expected in healthy individuals.
resultsWe find that in the region of the temporal poles, the expected EF strength may reach amplitudes in the order of 0.1-1 V/m.
conclusionThe cortical EF caused by natural chewing could be large enough to modulate ongoing neural activity in the cerebral cortex and influence cognitive performance. SIGNIFICANCE: The present study lends first support for the assumption that extracranial muscle activity might represent an endogenous source of electrical brain stimulation. This offers a new potential explanation for the puzzling effects of gum chewing on cognition, which have been repeatedly reported in the literature.
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