Evidence map›Paper›PMID 27448307›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

From glioblastoma to endothelial cells through extracellular vesicles: messages for angiogenesis.

Ilaria Giusti, Simona Delle Monache, Marianna Di Francesco, Patrizia Sanità, Sandra D'Ascenzo, Giovanni Luca Gravina, Claudio Festuccia, Vincenza Dolo

Abstract read
PubMed Publisher
In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

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  19. G protein-coupled receptors: a gateway to targeting oncogenic EVs?Extracellular vesicles and circulating nucleic acids · 2024
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ilaria GiustiDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio-Coppito 2, I-67100, L'Aquila, Italy.
Simona Delle MonacheDepartment of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, Via Vetoio-Coppito 2, I-67100, L'Aquila, Italy.
Marianna Di FrancescoDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio-Coppito 2, I-67100, L'Aquila, Italy.
Patrizia SanitàDepartment of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, Via Vetoio-Coppito 2, I-67100, L'Aquila, Italy.
Sandra D'AscenzoDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio-Coppito 2, I-67100, L'Aquila, Italy.
Giovanni Luca GravinaDepartment of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, Via Vetoio-Coppito 2, I-67100, L'Aquila, Italy.
Claudio FestucciaDepartment of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, Via Vetoio-Coppito 2, I-67100, L'Aquila, Italy.
Vincenza DoloDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio-Coppito 2, I-67100, L'Aquila, Italy. vincenza.dolo@univaq.it.
University of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma has one of the highest mortality rates among cancers, and it is the most common and malignant form of brain cancer. Among the typical features of glioblastoma tumors, there is an aberrant vascularization: all gliomas are among the most vascularized/angiogenic tumors. In recent years, it has become clear that glioblastoma cells can secrete extracellular vesicles which are spherical and membrane-enclosed particles released, in vitro or in vivo, by both normal and tumor cells; they are involved in the regulation of both physiological and pathological processes; among the latter, cancer is the most widely studied. Extracellular vesicles from tumor cells convey messages to other tumor cells, but also to normal stromal cells in order to create a microenvironment that supports cancer growth and progression and are implicated in drug resistance, escape from immunosurveillance and from apoptosis, as well as in metastasis formation; they are also involved in angiogenesis stimulation, inducing endothelial cells proliferation, and other pro-angiogenic activities. To this aim, the present paper assesses in detail the extracellular vesicles phenomenon in the human glioblastoma cell line U251 and evaluates extracellular vesicles ability to promote the processes required to achieve the formation of new blood vessels in human brain microvascular endothelial cells, highlighting that they stimulate proliferation, motility, and tube formation in a dose-response manner. Moreover, a molecular characterization shows that extracellular vesicles are fully equipped for angiogenesis stimulation in terms of proteolytic enzymes (gelatinases and plasminogen activators), pro-angiogenic growth factors (VEGF and TGFβ), and the promoting-angiogenic CXCR4 chemokine receptor.

Indexed as

Blood VesselsBlotting, WesternCell-Derived MicroparticlesCell Line, TumorCell ProliferationCells, CulturedCulture Media, ConditionedEndothelial CellsExosomesExtracellular VesiclesGlioblastomaHumansMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionNeovascularization, PathologicReceptors, CXCR4Culture Media, ConditionedReceptors, CXCR4Transforming Growth Factor betaVascular Endothelial Growth Factor AAngiogenesisCXCR4Endothelial cellsExtracellular vesiclesHuman glioblastomaU251 cells

Identifiers

PMID27448307
OpenAlexW2487212353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.