ArticleThe Journal of comparative neurology2017
Heterogeneity of astrocyte and NG2 cell insertion at the node of ranvier.
Article in The Journal of comparative neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Glutamate signaling and transport around nodes of Ranvier and internodal myelin regions.Histology and histopathology · 2026Review
- Article
- From synapse to sheath: how OPCs couple neural activity to adaptive myelination and behavioral plasticity.Frontiers in cell and developmental biology · 2026Review
- Exploring neuro-glial interaction mechanisms in myelin plasticity for learning and memory enhancement.Journal of molecular histology · 2025Article
- Morphology of Oligodendroglial Cells.Advances in neurobiology · 2025Review
- Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex.Neuron · 2024Review
- Functional myelin in cognition and neurodevelopmental disorders.Cellular and molecular life sciences : CMLS · 2024Review
- Glial modulation of synapse development and plasticity: oligodendrocyte precursor cells as a new player in the synaptic quintet.Frontiers in cell and developmental biology · 2024Review
- Unlocking the Potential: immune functions of oligodendrocyte precursor cells.Frontiers in immunology · 2024Review
- Intrinsic organization of the corpus callosum.Frontiers in physiology · 2024Review
- Reduced length of nodes of Ranvier and altered proteoglycan immunoreactivity in prefrontal white matter in major depressive disorder and chronically stressed rats.Scientific reports · 2023Article
- Oligodendrocyte precursor cells: the multitaskers in the brain.Pflugers Archiv : European journal of physiology · 2023Review
- Axonal energy metabolism, and the effects in aging and neurodegenerative diseases.Molecular neurodegeneration · 2023Review
- AAV Vector Mediated Delivery of NG2 Function Neutralizing Antibody and Neurotrophin NT-3 Improves Synaptic Transmission, Locomotion, and Urinary Tract Function after Spinal Cord Contusion Injury in Adult Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Astrocytes as Context for the Involvement of Myelin and Nodes of Ranvier in the Pathophysiology of Depression and Stress-Related Disorders.Journal of psychiatry and brain science · 2023Article
- Photonics tools begin to clarify astrocyte calcium transients.Neurophotonics · 2022Review
- Localized astrogenesis regulates gyrification of the cerebral cortex.Science advances · 2022Article
- Clusters of neuronal neurofascin prefigure the position of a subset of nodes of Ranvier along individual central nervous system axons in vivo.Cell reports · 2022Article
- Blood-nerve barrier disruption and coagulation system activation induced by mechanical compression injury participate in the peripheral sensitization of trigeminal neuralgia.Frontiers in molecular neuroscience · 2022Article
- Chondroitin Sulphate Proteoglycan Axonal Coats in the Human Mediodorsal Thalamic Nucleus.Frontiers in integrative neuroscience · 2022Article
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3 authors.
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Abstract
The node of Ranvier is a functionally important site on the myelinated axon where sodium channels are clustered and regeneration of action potentials occurs, allowing fast saltatory conduction of action potentials. Early ultrastructural studies have revealed the presence of "glia" or "astrocytes" at the nodes. NG2 cells, also known as oligodendrocyte precursor cells or polydendrocytes, which are a resident glial cell population in the mature mammalian central nervous system that is distinct from astrocytes, have also been shown to extend processes that contact the nodes. However, the prevalence of the two types of glia at the node has remained unknown. We have used specific cell surface markers to examine the association of NG2 cells and astrocytes with the nodes of Ranvier in the optic nerve, corpus callosum, and spinal cord of young adult mice or rats. We show that more than 95% of the nodes in all three regions contained astrocyte processes, while 33-49% of nodes contained NG2 cell processes. NG2 cell processes were associated more frequently with larger nodes. A few nodes were devoid of glial apposition. Electron microscopy and stimulated emission depletion (STED) super-resolution microscopy confirmed the presence of dual glial insertion at some nodes and further revealed that NG2 cell processes contacted the nodal membrane at discrete points, while astrocytes had broader processes that surrounded the nodes. The study provides the first systematic quantitative analysis of glial cell insertions at central nodes of Ranvier. J. Comp. Neurol. 525:535-552, 2017. © 2016 Wiley Periodicals, Inc.
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