ReviewInfection2017
Bacterial coinfections in dengue virus disease: what we know and what is still obscure about an emerging concern.
Review in Infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- Culture-Negative Septic Pulmonary Embolism Secondary to Lower-Limb Cellulitis Following Recent Dengue Fever Complicated by Hydropneumothorax: A Case Report.Clinical case reports · 2026Article
- Clinical profiles and predictors of survival in severe dengue cases.Singapore medical journal · 2026Article
- Use of single-pass albumin dialysis in a patient with acute liver failure due to dengue: A case reportBiomedica : revista del Instituto Nacional de Salud · 2026Article
- Dual Infection with dengue virus and infective endocarditis leading to brain abscess, multiorgan infarctions, and horner syndrome: a case report with literature review.BMC cardiovascular disorders · 2026Review
- Zika immune imprint risks dengue.Nature immunology · 2026Article
- Severe dengue in adults admitted to intensive care units on réunion island: clinical spectrum, outcomes, and predictors of mortality.Critical care (London, England) · 2025Article
- Coinfection with Respiratory Pathogens and Dengue Disease Severity in Puerto Rico, 2012-2024.The American journal of tropical medicine and hygiene · 2025Article
- False-positive dengue non-structural protein 1 in pregnancy.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025Article
- Role of soluble interleukin-2 receptor (sIL-2R) as a predictor for severe dengue infection.Scientific reports · 2025Observational
- Unveiling Hyperinflammation in Severe Dengue With Coinfection Among Children: A Case Series.Cureus · 2025Article
- Oral Candidiasis in Acute Flaviviral Infection.The American journal of tropical medicine and hygiene · 2025Article
- Comparative analysis of blood routine, C-reactive protein, and biochemical markers in children withFrontiers in pediatrics · 2025Article
- Article
- Serosurveillance of dengue infection and correlation with mosquito pools for dengue virus positivity during the COVID-19 pandemic in Tamil Nadu, India - A state-wide cross-sectional cluster randomized community-based study.medRxiv : the preprint server for health sciences · 2024Article
- Attrition in serum anti-DENV antibodies correlates with high anti-SARS-CoV-2 IgG levels and low DENV positivity in mosquito vectors-Findings from a state-wide cluster-randomized community-based study in Tamil Nadu, India.PLOS global public health · 2024Article
- Severe dengue in the intensive care unit.Journal of intensive medicine · 2024Review
- Dual RNA-Seq reveals transcriptionally active microbes (TAMs) dynamics in the serum of dengue patients associated with disease severity.Frontiers in microbiology · 2023Article
- C-reactive protein: An easy marker for early differentiation between leptospirosis and dengue fever in endemic area.PloS one · 2023Article
- Concurrent and Subsequent Co-Infections ofMicroorganisms · 2022Review
- The characteristics of bacteremia among patients with acute febrile illness requiring hospitalization in Indonesia.PloS one · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDengue virus is the most frequent arthropod-borne viral infection worldwide. Simultaneously to the growth of its incidence, cases of bacterial coinfection in dengue have been increasingly reported. The clinical course of dual infections may worsen for reciprocal interactions and delays in the diagnosis, so that clinicians should be aware of this eventuality. Therefore, we reviewed literature to provide an overview of the epidemiological, clinical, and physiopathological issues related to bacterial coinfections and bacteremia in dengue.
methodsClinical studies and case reports regarding bacteremia and bacterial coinfections in dengue and the interactions between the pathogens published on PubMed were reviewed.
resultsWe found 26 case reports, only 3 studies on concurrent bacteremia and 12 studies reporting data on bacterial coinfections in dengue. According to the three available studies, the 0.18-7 % of dengue infections are accompanied by concurrent bacteremia, while the 14.3-44.4 % of dengue-related deaths seem associated to bacterial coinfections. Comorbidities, advanced age, and more severe dengue manifestations could be risk factors for dual infections. A longer duration of fever and alterations in laboratory parameters such as procalcitonin, hyponatremia, leukocyte count, and renal function tests can raise the suspicion.
conclusionsDespite the real burden and consequences of this emerging concern is still not computable accurately due to the lack of a significant number of studies on large cohorts, clinicians need a greater awareness about it to early recognize warning signs, to properly use available diagnostic tools and to readily start antibiotic treatment able to prevent worsening in mortality and morbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.