ArticleNanoscale research letters2016
Sensitive and Selective Detection of HIV-1 RRE RNA Using Vertical Silicon Nanowire Electrode Array.
Article in Nanoscale research letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Micro/Nano Electrode Array Sensors: Advances in Fabrication and Emerging Applications in Bioanalysis.Frontiers in chemistry · 2020Review
- Nanosilicon-Based Composites for (Bio)sensing Applications: Current Status, Advantages, and Perspectives.Materials (Basel, Switzerland) · 2019Review
- Nanobiosensing with Arrays and Ensembles of Nanoelectrodes.Sensors (Basel, Switzerland) · 2016Review
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Authors and funding
8 authors.
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Abstract
In this study, HIV-1 Rev response element (RRE) RNA was detected via an Au-coated vertical silicon nanowire electrode array (VSNEA). The VSNEA was fabricated by combining bottom-up and top-down approaches and then immobilized by artificial peptides for the recognition of HIV-1 RRE. Differential pulse voltammetry (DPV) analysis was used to measure the electrochemical response of the peptide-immobilized VSNEA to the concentration and types of HIV-1 RRE RNA. DPV peaks showed linearity to the concentration of RNA with a detection limit down to 1.513 fM. It also showed the clear different peaks to the mutated HIV-1 RRE RNA. The high sensitivity and selectivity of VSNEA for the detection of HIV-1 RRE RNA may be attributed to the high surface-to-volume ratio and total overlap diffusion mode of ions of the one-dimensional nanowire electrodes.
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