Evidence map›Paper›PMID 27447983›Full record

ArticleMolecular cell2016

Structures of the m(6)A Methyltransferase Complex: Two Subunits with Distinct but Coordinated Roles.

Katherine I Zhou, Tao Pan

Abstract readComment
In one paragraph

Article in Molecular cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. METTL14 MediatesRedox report : communications in free radical research · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Roles of mInternational journal of oncology · 2023
    Review
  19. mFrontiers in immunology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Katherine I ZhouMedical Scientist Training Program, The University of Chicago, Chicago, IL 60637, USA.
Tao PanDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Institute of Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA. Electronic address: taopan@uchicago.edu.

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
Role of m6A in HNRNPG protein localization and HNRNPG-regulated alternative splicingF30GM120917 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHOU, KATHERINE ISMEI · 2016 to 2018
$147k
NIGMS NIH HHS F30 GM120917NIGMS NIH HHS T32 GM007281
6 · The paper itself

Abstract

In this issue of Molecular Cell, Wang et al. (2016a) report crystal structures of the core of the METTL3/METTL14 m(6)A methyltransferase complex and propose how the two subunits interact and cooperate to bind and methylate RNA.

Indexed as

MethyltransferasesRNAMethyltransferasesRNA

Identifiers

PMID27447983
PMCPMC5109923

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.