ArticlePloS one2016
Effect of Low-Dose MDCT and Iterative Reconstruction on Trabecular Bone Microstructure Assessment.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Computed tomography with low-dose radiation versus standard-dose radiation for diagnosing fractures: systematic review and meta-analysis.Sao Paulo medical journal = Revista paulista de medicinaPooled it
- Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density-independent manner.JOR spine · 2022Article
- X-ray-based quantitative osteoporosis imaging at the spine.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Review
- Bone mineral density assessment using iterative reconstruction compared with quantitative computed tomography as the standard of reference.Scientific reports · 2018Article
- Effect of radiation dose reduction on texture measures of trabecular bone microstructure: an in vitro study.Journal of bone and mineral metabolism · 2018Article
- Is multidetector CT-based bone mineral density and quantitative bone microstructure assessment at the spine still feasible using ultra-low tube current and sparse sampling?European radiology · 2017Article
- Effect of Low-Dose MDCT and Iterative Reconstruction on Trabecular Bone Microstructure Assessment.PloS one · 2016Article
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10 authors.
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Abstract
We investigated the effects of low-dose multi detector computed tomography (MDCT) in combination with statistical iterative reconstruction algorithms on trabecular bone microstructure parameters. Twelve donated vertebrae were scanned with the routine radiation exposure used in our department (standard-dose) and a low-dose protocol. Reconstructions were performed with filtered backprojection (FBP) and maximum-likelihood based statistical iterative reconstruction (SIR). Trabecular bone microstructure parameters were assessed and statistically compared for each reconstruction. Moreover, fracture loads of the vertebrae were biomechanically determined and correlated to the assessed microstructure parameters. Trabecular bone microstructure parameters based on low-dose MDCT and SIR significantly correlated with vertebral bone strength. There was no significant difference between microstructure parameters calculated on low-dose SIR and standard-dose FBP images. However, the results revealed a strong dependency on the regularization strength applied during SIR. It was observed that stronger regularization might corrupt the microstructure analysis, because the trabecular structure is a very small detail that might get lost during the regularization process. As a consequence, the introduction of SIR for trabecular bone microstructure analysis requires a specific optimization of the regularization parameters. Moreover, in comparison to other approaches, superior noise-resolution trade-offs can be found with the proposed methods.
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