ArticleMarine drugs2016
New Cyclotetrapeptides and a New Diketopiperzine Derivative from the Marine Sponge-Associated Fungus Neosartorya glabra KUFA 0702.
Article in Marine drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Review
- Peptides from Marine-Derived Fungi: Chemistry and Biological Activities.Marine drugs · 2023Review
- Cyclic Peptides in Pipeline: What Future for These Great Molecules?Pharmaceuticals (Basel, Switzerland) · 2023Review
- New Hybrid Phenalenone Dimer, Highly Conjugated Dihydroxylated CMarine drugs · 2023Article
- Absolute Stereochemistry Determination of Bioactive Marine-Derived Cyclopeptides by Liquid Chromatography Methods: An Update Review (2018-2022).Molecules (Basel, Switzerland) · 2023Review
- Marine Cyclic Peptides: Antimicrobial Activity and Synthetic Strategies.Marine drugs · 2022Review
- Bioactive Compounds from Terrestrial and Marine-Derived Fungi of the GenusMolecules (Basel, Switzerland) · 2022Review
- Marine-Derived Indole Alkaloids and Their Biological and Pharmacological Activities.Marine drugs · 2021Review
- Marine Indole Alkaloids-Isolation, Structure and Bioactivities.Marine drugs · 2021Review
- Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods.Molecules (Basel, Switzerland) · 2021Review
- Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants.Marine drugs · 2021Article
- Structures and Biological Activities of Diketopiperazines from Marine Organisms: A Review.Marine drugs · 2021Review
- Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures.Marine life science & technology · 2021Review
- New azaphilones from Aspergillus neoglaber.AMB Express · 2020Article
- Classification ofStudies in mycology · 2020Article
- Biological and Chemical Diversity of Marine Sponge-Derived Microorganisms over the Last Two Decades from 1998 to 2017.Molecules (Basel, Switzerland) · 2020Review
- A newPeerJ · 2020Article
- TheMarine drugs · 2018Article
- Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review.Molecules (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two new cyclotetrapeptides, sartoryglabramides A (5) and B (6), and a new analog of fellutanine A (8) were isolated, together with six known compounds including ergosta-4, 6, 8 (14), 22-tetraen-3-one, ergosterol 5, 8-endoperoxide, helvolic acid, aszonalenin (1), (3R)-3-(1H-indol-3-ylmethyl)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione (2), takakiamide (3), (11aR)-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione (4), and fellutanine A (7), from the ethyl acetate extract of the culture of the marine sponge-associated fungus Neosartorya glabra KUFA 0702. The structures of the new compounds were established based on extensive 1D and 2D spectral analysis. X-ray analysis was also used to confirm the relative configuration of the amino acid constituents of sartoryglabramide A (5), and the absolute stereochemistry of the amino acid constituents of sartoryglabramide A (5) and sartoryglabramides B (6) was determined by chiral HPLC analysis of their hydrolysates by co-injection with the d- and l- amino acids standards. Compounds 1-8 were tested for their antibacterial activity against Gram-positive (Escherichia coli ATCC 25922) and Gram-negative (Staphyllococus aureus ATCC 25923) bacteria, as well as for their antifungal activity against filamentous (Aspergillus fumigatus ATCC 46645), dermatophyte (Trichophyton rubrum ATCC FF5) and yeast (Candida albicans ATCC 10231). None of the tested compounds exhibited either antibacterial (MIC > 256 μg/mL) or antifungal activities (MIC > 512 μg/mL).
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