ArticlePhysical review letters2016
Virtual k-Space Modulation Optical Microscopy.
Article in Physical review letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Cellular optical imaging techniques: a dynamic advancing frontier.Science China. Life sciences · 2025Review
- Optical sectioning methods in three-dimensional bioimaging.Light, science & applications · 2025Review
- Review of bio-optical imaging systems with a high space-bandwidth product.Advanced photonics · 2021Article
- Rapid Image Reconstruction of Structured Illumination Microscopy Directly in the Spatial Domain.IEEE photonics journal · 2021Article
- Virtual single-pixel imaging-based deconvolution method for spatial resolution improvement in wide-field fluorescence microscopy.Biomedical optics express · 2020Article
- Structured illumination imaging without grating rotation based on mirror operation on 1D Fourier spectrum.Optics express · 2019Article
- Terapixel hyperspectral whole-slide imaging via slit-array detection and projection.Journal of biomedical optics · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We report a novel superresolution microscopy approach for imaging fluorescence samples. The reported approach, termed virtual k-space modulation optical microscopy (VIKMOM), is able to improve the lateral resolution by a factor of 2, reduce the background level, improve the optical sectioning effect and correct for unknown optical aberrations. In the acquisition process of VIKMOM, we used a scanning confocal microscope setup with a 2D detector array to capture sample information at each scanned x-y position. In the recovery process of VIKMOM, we first modulated the captured data by virtual k-space coding and then employed a ptychography-inspired procedure to recover the sample information and correct for unknown optical aberrations. We demonstrated the performance of the reported approach by imaging fluorescent beads, fixed bovine pulmonary artery endothelial (BPAE) cells, and living human astrocytes (HA). As the VIKMOM approach is fully compatible with conventional confocal microscope setups, it may provide a turn-key solution for imaging biological samples with ∼100 nm lateral resolution, in two or three dimensions, with improved optical sectioning capabilities and aberration correcting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.