Trial reportAnnals of neurology2016
Dose response of task-specific upper limb training in people at least 6 months poststroke: A phase II, single-blind, randomized, controlled trial.
Trial report in Annals of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 117 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fast Training Promotes Recovery of Arm Movements Post-stroke Via Cerebellar-mediated Anticipatory Feedforward Control
Pilot Testing of tDCS and Metacognitive Strategy Training in Chronic Stroke
Comparative Effects of Constraint-Induced Movement Therapy (CIMT) with Motor Relearning Program (MRP) and Bobath Approach to Augment Functional Motor Recovery of Chronic Hemiparetic Arm
Comparative Effects of Resistance Training and Constrained Induced Movement Therapy on Upper Extremity Motor Recovery and Quality of Life in Sub-acute Stroke Patients
Who cites it
117 citing papers in PubMed, 1 synthesis or guideline pooled it, 238 citations in OpenAlex.
- The effect of time spent in rehabilitation on activity limitation and impairment after stroke.The Cochrane database of systematic reviews · 2021Pooled it
- Enhancing spontaneous recovery after stroke: a randomized controlled trial.Brain communications · 2026Trial
- Biofeedback Training for 3-Dimensional Finger Force Control to Improve Upper Limb Function Poststroke: An RCT.Stroke · 2025Trial
- Task Practice With and Without Aerobic Exercise Improves Health-related Quality of Life and Social Participation Post-stroke: A Randomized Clinical Trial.Neurorehabilitation and neural repair · 2025Trial
- A Randomized Control Trial of a Virtually Delivered Program for Increasing Upper Limb Activity After Stroke.Neurorehabilitation and neural repair · 2025Trial
- The influence of scaffolding on intrinsic motivation and autonomous adherence to a game-based, sparsely supervised home rehabilitation program for people with upper extremity hemiparesis due to stroke. A randomized controlled trial.Journal of neuroengineering and rehabilitation · 2024Trial
- The Utilization of Forced-Rate Cycling to Facilitate Motor Recovery Following Stroke: A Randomized Clinical Trial.Neurorehabilitation and neural repair · 2024Trial
- Trial
- Therapy effect on hand function after home use of a wearable assistive soft-robotic glove supporting grip strength.PloS one · 2024Trial
- Early and intensive Motor Training for people with spinal cord injuries (the SCI-MT Trial): description of the intervention.Spinal cord · 2023Trial
- Motor Activated Auricular Vagus Nerve Stimulation as a Potential Neuromodulation Approach for Post-Stroke Motor Rehabilitation: A Pilot Study.Neurorehabilitation and neural repair · 2023Trial
- Concomitant sensory stimulation during therapy to enhance hand functional recovery post stroke.Trials · 2022Trial
- Efficacy of a technology-based client-centred training system in neurological rehabilitation: a randomised controlled trial.Journal of neuroengineering and rehabilitation · 2021Trial
- Using a bimanual lever-driven wheelchair for arm movement practice early after stroke: A pilot, randomized, controlled, single-blind trial.Clinical rehabilitation · 2021Trial
- Critical Period After Stroke Study (CPASS): A phase II clinical trial testing an optimal time for motor recovery after stroke in humans.Proceedings of the National Academy of Sciences of the United States of America · 2021Trial
- Behavioral and neurophysiological effects of an intensified robot-assisted therapy in subacute stroke: a case control study.Journal of neuroengineering and rehabilitation · 2021Trial
- Evaluation of the enhanced upper limb therapy programme within the Robot-Assisted Training for the Upper Limb after Stroke trial: descriptive analysis of intervention fidelity, goal selection and goal achievement.Clinical rehabilitation · 2021Trial
- Gains Across WHO Dimensions of Function After Robot-Based Therapy in Stroke Subjects.Neurorehabilitation and neural repair · 2020Trial
- Exploratory study of how Cognitive Multisensory Rehabilitation restores parietal operculum connectivity and improves upper limb movements in chronic stroke.Scientific reports · 2020Trial
- Relationships between accelerometry and general compensatory movements of the upper limb after stroke.Journal of neuroengineering and rehabilitation · 2020Trial
57 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe objectives of this work were to (1) determine whether higher doses of motor therapy in chronic poststroke hemiparesis result in better outcomes, compared to lower doses, and (2) evaluate potential modifiers of the dose-response relationship.
methodsEighty-five adults with upper extremity paresis ≥6 months poststroke were randomized to one of four dose groups in this single-blind, parallel, randomized, control trial. The dosing parameter manipulated was amount of task-specific training, as indexed by the number of task repetitions. Groups received 3,200, 6,400, 9,600, or individualized maximum (IM) repetitions, during 1-hour sessions, 4 days/week for 8 weeks. The intervention was an individualized, progressive, task-specific upper-limb training program designed to improve upper-limb functional motor capacity. The primary outcome was the slope of the Action Research Arm Test (ARAT) during the intervention. Effects of dose and potential modifiers of the dose-response relationship were evaluated with hierarchical linear models.
resultsARAT scores for the 3,200, 9,600, and IM groups improved over time as indicated by slopes (ΔARAT/week, mean ± standard errors) of 0.40 ± 0.15, 0.31 ± 0.16, and 0.66 ± 0.14, respectively (p < 0.05). The slope of the 6,400 group was smaller (-0.05 ± 0.15) and significantly different from the 3,200 and IM groups (p < 0.001). Initial motor capacity, neglect, and other tested characteristics did not modify the dose-response relationship.
interpretationOverall, treatment effects were small. There was no evidence of a dose-response effect of task-specific training on functional capacity in people with long-standing upper-limb paresis poststroke. Ann Neurol 2016;80:342-354.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.