Evidence map›Paper›PMID 27447361›Full record

ArticleOrganic letters2016

Synthesis of Oligodeoxynucleotides Containing Electrophilic Groups.

Xi Lin, Jinsen Chen, Shahien Shahsavari, Nathanael Green, Deepti Goyal, Shiyue Fang

Abstract read
In one paragraph

Article in Organic letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. GuanineOrganic & biomolecular chemistry · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Oligonucleotide synthesis under mild deprotection conditions.New journal of chemistry = Nouveau journal de chimie · 2023
    Article
  6. Dim and Dmoc Protecting Groups for Oligodeoxynucleotide Synthesis.Current protocols in nucleic acid chemistry · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. dM-Dim for Carboxylic Acid Protection.Tetrahedron letters · 2018
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xi LinDepartment of Chemistry, Michigan Technological University , 1400 Townsend Drive, Houghton, Michigan 49931, United States.
Jinsen ChenDepartment of Chemistry, Michigan Technological University , 1400 Townsend Drive, Houghton, Michigan 49931, United States.
Shahien ShahsavariDepartment of Chemistry, Michigan Technological University , 1400 Townsend Drive, Houghton, Michigan 49931, United States.
Nathanael GreenDepartment of Chemistry, Michigan Technological University , 1400 Townsend Drive, Houghton, Michigan 49931, United States.
Deepti GoyalDepartment of Chemistry, Michigan Technological University , 1400 Townsend Drive, Houghton, Michigan 49931, United States.
Shiyue FangDepartment of Chemistry, Michigan Technological University , 1400 Townsend Drive, Houghton, Michigan 49931, United States.

Funding

Synthesis of Sensitive Epitranscriptomically Modified RNAsR15GM109288 · NIGMS · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI FANG, SHIYUE · 2014 to 2024
$1.3M
NIGMS NIH HHS R15 GM109288
6 · The paper itself

Abstract

By use of 1,3-dithian-2-yl-methoxycarbonyl (Dmoc) as a protecting group and linker for oligodeoxynucleotide (ODN) synthesis, deprotection and cleavage are achieved under non-nucleophilic oxidative conditions. The nucleophile-sensitive thioester and α-chloroacetyl groups are conveniently incorporated into ODN sequences. The technology could be universally useful for electrophilic ODN synthesis.

Indexed as

Molecular ConformationOligodeoxyribonucleotidesOligodeoxyribonucleotides

Identifiers

PMID27447361
PMCPMC4975647

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.