Evidence map›Paper›PMID 27447351›Full record

ArticleClinical transplantation2016

Medication understanding, non-adherence, and clinical outcomes among adult kidney transplant recipients.

Rachel E Patzer, Marina Serper, Peter P Reese, Kamila Przytula, Rachel Koval, Daniela P Ladner, Josh M Levitsky, Michael M Abecassis, Michael S Wolf

Abstract read
In one paragraph

Article in Clinical transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Health Literacy in Surgery.Health literacy research and practice · 2020
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. A Multifaceted Intervention to Improve Patient Knowledge and Safe Use of Opioids: Results of the ED EMCAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2019
    Trial
  9. Trial
  10. Article
  11. Article
  12. Article
  13. Review
  14. The Role of Health Literacy in Gastrointestinal Cancer Patients' Surgical Journey: A Qualitative Study.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026
    Article
  15. Article
  16. Article
  17. Cognitive impairment in kidney transplanted patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rachel E PatzerDivision of Transplantation, Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA. rpatzer@emory.edu.
Marina SerperDivision of Gastroenterology and Hepatology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Peter P ReeseRenal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kamila PrzytulaHealth Literacy and Learning Program, Division of General Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Rachel KovalDivision of Transplantation, Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA.
Daniela P LadnerComprehensive Transplant Center (CTC), Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Josh M LevitskyComprehensive Transplant Center (CTC), Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Michael M AbecassisComprehensive Transplant Center (CTC), Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Michael S WolfDivision of General Internal Medicine and Geriatrics, Department of Medicine, Northwestern University School of Medicine, Chicago, IL, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Transplant Surgery Scientist Training ProgramT32DK077662 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Richard M Green, Daniela P Ladner · 2007 to 2026
$3.8M
User-Centered, Web-based Portal to Support Regimen Adherence in TransplantR21NR014544 · NINR · EMORY UNIVERSITY · PI PATZER, RACHEL E · 2015 to 2016
$442k
NCI NIH HHS P30 CA060553NIDDK NIH HHS T32 DK077662NIMHD NIH HHS L60 MD007236NINR NIH HHS R21 NR014544
6 · The paper itself

Abstract

We sought to evaluate the prevalence of medication understanding and non-adherence of entire drug regimens among kidney transplantation (KT) recipients and to examine associations of these exposures with clinical outcomes. Structured, in-person interviews were conducted with 99 adult KT recipients between 2011 and 2012 at two transplant centers in Chicago, IL; and Atlanta, GA. Nearly, one-quarter (24%) of participants had limited literacy as measured by the Rapid Estimate of Adult Literacy in Medicine test; patients took a mean of 10 (SD=4) medications and 32% had a medication change within the last month. On average, patients knew what 91% of their medications were for (self-report) and demonstrated proper dosing (via observed demonstration) for 83% of medications. Overall, 35% were non-adherent based on either self-report or tacrolimus level. In multivariable analyses, fewer months since transplant and limited literacy were associated with non-adherence (all P<.05). Patients with minority race, a higher number of medications, and mild cognitive impairment had significantly lower treatment knowledge scores. Non-white race and lower income were associated with higher rates of hospitalization within a year following the interview. The identification of factors that predispose KT recipients to medication misunderstanding, non-adherence, and hospitalization could help target appropriate self-care interventions.

Indexed as

ComprehensionDrug MonitoringHealth Knowledge, Attitudes, PracticeKidney TransplantationAdolescentAdultAgedAged, 80 and overFemaleGraft RejectionHealth LiteracyHospitalizationHumansImmunosuppressive AgentsMaleMedication AdherenceImmunosuppressive Agentscognitionhospitalizationkidney transplantationliteracymedication adherence

Identifiers

PMID27447351
PMCPMC5061615

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.