Evidence map›Paper›PMID 27447346›Full record

ArticleChemical communications (Cambridge, England)2016

Direct detection of nitrotyrosine-containing proteins using an aniline-based oxidative coupling strategy.

Rapeepat Sangsuwan, Allie C Obermeyer, Phum Tachachartvanich, Krishnan K Palaniappan, Matthew B Francis

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rapeepat SangsuwanDepartment of Chemistry, University of California, Berkeley, CA 94720-1460, USA. mbfrancis@berkeley.edu.
Allie C Obermeyer
Phum Tachachartvanich
Krishnan K Palaniappan
Matthew B Francis

Funding

Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
Targeted Imaging Agents Based on Synthetically Modified Viral CapsidsR21EB018055 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI FRANCIS, MATTHEW B · 2014 to 2015
$392k
NIBIB NIH HHS R21 EB018055NIGMS NIH HHS T32 GM066698
6 · The paper itself

Abstract

A convenient two-step method is described for the detection of nitrotyrosine-containing proteins. First, nitrotyrosines are reduced to aminophenols using sodium dithionite. Following this, an oxidative coupling reaction is used to attach anilines bearing fluorescence reporters or affinity probes. Features of this approach include fast reaction times, pmol-level sensitivity, and excellent chemoselectivity.

Indexed as

Aniline CompoundsDithioniteFluorescenceFluorescent DyesMolecular StructureOxidation-ReductionProteinsTyrosine3-nitrotyrosineanilineAniline CompoundsDithioniteFluorescent DyesProteinsTyrosine

Identifiers

PMID27447346
PMCPMC5001876

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.